Polycythemia: Difference between revisions
ClaireLewis (talk | contribs) (Removed redirect to Polycythemia vera) Tag: Removed redirect |
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*Primary polycythemia ([[myeloproliferative disorders]]) | *Primary polycythemia ([[myeloproliferative disorders]]) | ||
**[[Polycythemia vera]] | **[[Polycythemia vera]] | ||
**[[Essential thrombocytosis (ET | **[[Essential thrombocytosis]] (ET | ||
**[[Chronic myelogenous leukemia]] (CML) | **[[Chronic myelogenous leukemia]] (CML) | ||
**[[Leukemoid Reaction]] | **[[Leukemoid Reaction]] | ||
Latest revision as of 17:39, 1 October 2019
Background
- AKA erythrocytosis
- Refers to abnormally elevated Hb/Hct
Clinical Features
- Dependant on underlying etiology
- May be entirely asymptomatic
- Possible features include plethora, tendency towards thromboembolism or bleeding, splenomegaly, pruritus
Differential Diagnosis
- Primary polycythemia (myeloproliferative disorders)
- Secondary polycythemia (due to increased EPO)
- Chronic hypoxemia (e.g. COPD, physiologic altitude adaptations or chronic mountain sickness)
- Carboxyhemoglobin (chronic smokers)
- Renal cyst or hydronephrosis
- EPO-secreting tumors (RCC, hepatocellular carcinoma
- Anabolic steroid abuse
- Abnormal hemoglobins
Evaluation
- CBC
- Hb >17.5 (males) or >15.5 (females)
- Evaluate for underlying disease
Management
- Treat underlying pathology