Strychnine: Difference between revisions
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==Background== | ==Background== | ||
Strychnine is a highly toxic sabustance, it mimics generalized tetanus.It antagonizes glycine release, but unlike TS, it has no effect on GABA release. | Strychnine is a highly toxic sabustance, it mimics generalized tetanus.It antagonizes glycine release, but unlike TS, it has no effect on GABA release. | ||
==Clinical Features== | ==Clinical Features== | ||
*nausea and vomiting | |||
*opisthotonus while Pt. remaining alert | |||
*convulsions | |||
*eventually death through asphyxia | |||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
*generalized tetanus | |||
*Black widow spider bite | |||
*Dystonic reaction | |||
*stiff-man syndrome | |||
==Workup== | ==Workup== | ||
serum and urine tests for strychnine | serum and urine tests for strychnine | ||
==Management== | ==Management== | ||
*supportive management | |||
*benzo for [[seizure]] | |||
==Disposition== | ==Disposition== | ||
*all patients should be admitted | |||
==See Also== | ==See Also== | ||
*[[Tetanus]] | |||
==Sources== | ==Sources== | ||
<references/> | <references/> | ||
rosen, 7th edition p1684 | rosen, 7th edition p1684 | ||
http://en.wikipedia.org/wiki/Strychnine#Symptoms | http://en.wikipedia.org/wiki/Strychnine#Symptoms | ||
Revision as of 04:47, 28 May 2014
Background
Strychnine is a highly toxic sabustance, it mimics generalized tetanus.It antagonizes glycine release, but unlike TS, it has no effect on GABA release.
Clinical Features
- nausea and vomiting
- opisthotonus while Pt. remaining alert
- convulsions
- eventually death through asphyxia
Differential Diagnosis
- generalized tetanus
- Black widow spider bite
- Dystonic reaction
- stiff-man syndrome
Workup
serum and urine tests for strychnine
Management
- supportive management
- benzo for seizure
Disposition
- all patients should be admitted
See Also
Sources
rosen, 7th edition p1684 http://en.wikipedia.org/wiki/Strychnine#Symptoms