IV nitroglycerine alternatives: Difference between revisions
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==Background== | ==Background== | ||
*Suggestions for substitution during the IV shortage | *Suggestions for substitution during the IV shortage | ||
===Nitroglycerine Bioavailability=== | |||
*Oral <ref>http://sepia.unil.ch/pharmacology/index.php?id=51</ref>: <1% | |||
*Sublingual <ref>http://sepia.unil.ch/pharmacology/index.php?id=51</ref>: 38% (15-40%) | |||
*Topical <ref>http://sepia.unil.ch/pharmacology/index.php?id=51</ref>: 72% | |||
Half-life<http://sepia.unil.ch/pharmacology/index.php?id=60> (t1/2) 0.05 h | |||
==Suggested Substitutions<ref>http://www.medpagetoday.com/EmergencyMedicine/EmergencyMedicine/45056</ref>== | ==Suggested Substitutions<ref>http://www.medpagetoday.com/EmergencyMedicine/EmergencyMedicine/45056</ref>== | ||
Revision as of 00:34, 2 April 2014
Background
- Suggestions for substitution during the IV shortage
Nitroglycerine Bioavailability
Half-life<http://sepia.unil.ch/pharmacology/index.php?id=60> (t1/2) 0.05 h
Suggested Substitutions[4]
- Sublingual nitroglycerin, 1-2 tabs or sprays every 5 minutes as needed
- Once controlled
- Nitropursside OR Isordil PO (nitro paste or longer acting NTG)
- If not well controlled
- IV enalapril 0.625-1.25mg IV bolus
- IV hydralazine 5-10mg IV bolus
- IV nitropursside
- Once controlled
Source
<references>