Trimethoprim-Sulfamethoxazole DS: Difference between revisions
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==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | |||
*[[Stevens-Johnson Syndrome]] | |||
*[[Toxic Epidermal Necrolysis]] | |||
*Fulminant hepatic necrosis | |||
*Agranulocytosis | |||
*Aplastic anemia | |||
*Blood dyscrasias | |||
*[[Thrombocytopenia]] | |||
*[[Hypersensitivity Reaction]] | |||
*Photosensitivity | |||
*Hepatotoxicity | |||
*[[Pancreatitis]] | |||
*Intersitial nephritis | |||
*[[Renal Failure]] | |||
*Pulmonary infiltrates | |||
*Myelosuppression | |||
*Methhemoglobinemia | |||
*[[Hyperkalemia]] | |||
*[[Hyponatremia]] | |||
*Aseptic [[meningitis]] | |||
*[[Seizures]] | |||
*Lupus Erythematosus | |||
*[[Hypoglycemia]] | |||
*[[Clostridium difficile]] | |||
*[[Rhabdomyolysis]] | |||
*Congenital malformations | |||
*Congenital neural tube defects | |||
*[[Kernicterus]] (neonates) | |||
==Common== | |||
*[[Nausea and Vomiting]] | |||
*Anorexia | |||
*[[Rash]] | |||
*Urticaria | |||
*[[Hypersensitivity Reaction]] | |||
*Photosensitivity | |||
*[[Diarrhea]] | |||
*[[Dizziness]] | |||
*[[Dyspepsia]] | |||
*[[Headache]] | |||
*Lethargy | |||
==Pharmacology== | ==Pharmacology== | ||
Revision as of 21:50, 27 February 2014
General
- Type: Sulfonamide
- Dosage Forms: 160/800
- Common Trade Names: Bactrim DS
- Abbreviations: TMP-SMX, TMP-SMZ
Adult Dosing
General
1 tab (160mg TMP) PO Q12h
PCP Prophylaxis
80-160mg TMP PO daily
PCP Treatment
15-20 mg/kg/day TMP PO divided q6-8h x 21 days
Pediatric Dosing
General (>2mo)
- Mild-mod infection
- 4-5 mg/kg TMP PO q12hr
- Severe infection
- 15-20 mg/kg/dy TMP PO divided q6-8h
Contraindications
- Allergy to class/drug
- <2 months of age (except as PCP prophylaxis)
- sig hepatic impairment
- megaloblastic anemia or folate deficiency
- G6PD deficiency
Adverse Reactions
Serious
- Stevens-Johnson Syndrome
- Toxic Epidermal Necrolysis
- Fulminant hepatic necrosis
- Agranulocytosis
- Aplastic anemia
- Blood dyscrasias
- Thrombocytopenia
- Hypersensitivity Reaction
- Photosensitivity
- Hepatotoxicity
- Pancreatitis
- Intersitial nephritis
- Renal Failure
- Pulmonary infiltrates
- Myelosuppression
- Methhemoglobinemia
- Hyperkalemia
- Hyponatremia
- Aseptic meningitis
- Seizures
- Lupus Erythematosus
- Hypoglycemia
- Clostridium difficile
- Rhabdomyolysis
- Congenital malformations
- Congenital neural tube defects
- Kernicterus (neonates)
Common
- Nausea and Vomiting
- Anorexia
- Rash
- Urticaria
- Hypersensitivity Reaction
- Photosensitivity
- Diarrhea
- Dizziness
- Dyspepsia
- Headache
- Lethargy
Pharmacology
- Half-life: 6-12h (20-50h ESRD)
- Metabolism:
- Excretion:
- Mechanism of Action: Bactericidal
Pregnancy/Lactation
- Pregnancy: D
- Lactation: ?