Template:HIV post-exposure prophylaxis regimens: Difference between revisions
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===2 drug Basic<ref name="NEJM">Landovitz RJ, Currier JS. Postexposure prophylaxis for HIV infection. N Eng J Med. 2009 Oct 29; 361(18): 1768-75. [http://www.uphs.upenn.edu/ppmc_emergency/PPMC%20Bookmarks/2012%20LLSA%20Articles/Postexposure%20Prophylaxis%20for%20HIV.pdf PDF]</ref>===
===Preferred HIV [[PEP]] Regimen<ref>Kuhar D, et al. Updated US Public Health Service Guidelines for the Management of Occupational Exposures to Human Immunodeficiency Virus and Recommendations for Postexposure Prophylaxis. September 2013. 34(9):875-892. DOI: 10.1086/672271. http://www.jstor.org/stable/10.1086/672271</ref><ref>Updated Guidelines for Antiretroviral Postexposure Prophylaxis After Sexual, Injection Drug Use, or Other Nonoccupational Exposure to HIV—United States, 2016. Centers for Disease Control and Prevention, U.S. Department of Health and Human Services</ref>===
*[[Tenofovir-emtricitabine]] (Truvada) one tablet (300 mg of tenofovir with 200 mg of emtricitabine) once daily OR
*[[Raltegravir]] (Isentress; RAL) 400 mg PO twice daily, '''plus'''
*[[Zidovudine–lamivudine]] (Combivir) one tablet (300 mg of zidovudine with 150 mg of lamivudine) twice daily
*[[Truvada]], 1 PO once daily (Tenofovir DF [Viread; TDF] 300 mg emtricitabine [Emtriva; FTC] 200 mg)
**this regimen is preferred in pregancy


===3 drug Expanded<ref name="NEJM"></ref>===
===3 drug Expanded<ref name="NEJM"></ref>===

Revision as of 18:40, 19 November 2017

Preferred HIV PEP Regimen[1][2]

  • Raltegravir (Isentress; RAL) 400 mg PO twice daily, plus
  • Truvada, 1 PO once daily (Tenofovir DF [Viread; TDF] 300 mg emtricitabine [Emtriva; FTC] 200 mg)

3 drug Expanded[3]

  • Ritonavir–lopinavir (Kaletra) PLUS either tenofovir–emtricitabine or zidovudine–lamivudine)
    • Two tablets (50 mg of ritonavir with 200 mg of lopinavir per tablet) twice daily, or four tablets once daily
  • Ritonavir plus atazanavir (plus either tenofovir–emtricitabine or zidovudine–lamivudine
    • 100 mg of ritonavir plus 300 mg of atazanavir once daily
  • Ritonavir plus darunavir (plus either tenofovir–emtricitabine or zidovudine–lamivudine)
    • 100 mg of ritonavir plus two tablets, each containing 400 mg of darunavir, once daily
  1. ↑ Kuhar D, et al. Updated US Public Health Service Guidelines for the Management of Occupational Exposures to Human Immunodeficiency Virus and Recommendations for Postexposure Prophylaxis. September 2013. 34(9):875-892. DOI: 10.1086/672271. http://www.jstor.org/stable/10.1086/672271
  2. ↑ Updated Guidelines for Antiretroviral Postexposure Prophylaxis After Sexual, Injection Drug Use, or Other Nonoccupational Exposure to HIV—United States, 2016. Centers for Disease Control and Prevention, U.S. Department of Health and Human Services
  3. ↑ Cite error: Invalid <ref> tag; no text was provided for refs named NEJM
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