Droperidol: Difference between revisions
(Created page with "==Administration== *Type: antipsychotic *Dosage Forms: *Routes of Administration: *Common Trade Names: ==Adult Dosing== ===Combative patient=== *10mg IM ==Pediatric...") |
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==Administration== | ==Administration== | ||
*Type: [[antipsychotic]] | *Type: [[antipsychotic]], [[antiemetics]] | ||
*Dosage Forms: | *Dosage Forms: | ||
*Routes of Administration: | *Routes of Administration: IV/IM | ||
*Common Trade Names: | *Common Trade Names: | ||
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===[[Combative patient]]=== | ===[[Combative patient]]=== | ||
*10mg IM | *10mg IM | ||
===[[Headache]]=== | |||
*2.5mg IV or 2.5-5mg IM | |||
===[[Nausea/vomiting]]=== | |||
*0.625-2.5mg IV | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
===[[Nausea/vomiting]]=== | |||
*2-12yo: 0.015-0.1mg/kg IV/IM | |||
==Special Populations== | ==Special Populations== | ||
*[[Drug pregnancy categories|Pregnancy Rating]]: | *[[Drug pregnancy categories|Pregnancy Rating]]: C | ||
*Lactation risk: | *Lactation risk: Infant risk cannot be ruled out | ||
*Renal dosing: Administer with caution | |||
*Hepatic dosing: Administer with caution | |||
* | |||
==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
*Known or suspected prolonged QT | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*Prolonged QT, torsades, ventricular tachycardia, cardiac arrest | |||
**''Note: effect on QT interval is dose-dependent'' | |||
*Neuroleptic malignant syndrome | |||
*Anaphylaxis | |||
===Common=== | ===Common=== | ||
*Somnolence, dysphoria | |||
*Anxiety, restlessness, hyperactivity | |||
*Hypotension | |||
*Tachycardia | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 123-147m (adults), 75-127m (children) | ||
*Metabolism: | *Metabolism: hepatic | ||
*Excretion: | *Excretion: mostly renal | ||
==Mechanism of Action== | ==Mechanism of Action== | ||
*Dopamine (D2) antagonist. Some serotonergic, histaminergic, and alpha-adrenergic effect | |||
==Comments== | ==Comments== | ||
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==See Also== | ==See Also== | ||
*[[Antipsychotics]] | |||
*[[Combative patient]] | |||
==References== | ==References== | ||
Revision as of 14:54, 3 April 2017
Administration
- Type: antipsychotic, antiemetics
- Dosage Forms:
- Routes of Administration: IV/IM
- Common Trade Names:
Adult Dosing
Combative patient
- 10mg IM
Headache
- 2.5mg IV or 2.5-5mg IM
Nausea/vomiting
- 0.625-2.5mg IV
Pediatric Dosing
Nausea/vomiting
- 2-12yo: 0.015-0.1mg/kg IV/IM
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: Administer with caution
- Hepatic dosing: Administer with caution
Contraindications
- Allergy to class/drug
- Known or suspected prolonged QT
Adverse Reactions
Serious
- Prolonged QT, torsades, ventricular tachycardia, cardiac arrest
- Note: effect on QT interval is dose-dependent
- Neuroleptic malignant syndrome
- Anaphylaxis
Common
- Somnolence, dysphoria
- Anxiety, restlessness, hyperactivity
- Hypotension
- Tachycardia
Pharmacology
- Half-life: 123-147m (adults), 75-127m (children)
- Metabolism: hepatic
- Excretion: mostly renal
Mechanism of Action
- Dopamine (D2) antagonist. Some serotonergic, histaminergic, and alpha-adrenergic effect