Mebendazole: Difference between revisions
ClaireLewis (talk | contribs) (Created page with "==Administration== *Type: Antiparasitic (used to treat nematodes) *Dosage Forms: *Routes of Administration: Oral *Common Trade Names: ==Adult Dosing== *100mg PO BID x 3 days...") |
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==Administration== | ==Administration== | ||
*Type: Antiparasitic (used to treat nematodes) | *Type: [[Antiparasitic]] (used to treat nematodes) | ||
*Dosage Forms: | *Dosage Forms: | ||
*Routes of Administration: Oral | *Routes of Administration: Oral | ||
*Common Trade Names: | *Common Trade Names: | ||
==Adult Dosing== | ==Adult Dosing== | ||
Revision as of 17:58, 28 March 2017
Administration
- Type: Antiparasitic (used to treat nematodes)
- Dosage Forms:
- Routes of Administration: Oral
- Common Trade Names:
Adult Dosing
- 100mg PO BID x 3 days
Pediatric Dosing
≥2yo: 100mg PO BID x 3 days
Special Populations
- Pregnancy Rating: C
- Lactation risk: infant risk cannot be ruled out
- Renal dosing: no adjustment
- Hepatic impairment: may need dose reduction
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Agranulocytosis
- Hepatitis
- Seizure
- Angioedema
Common
- Abdominal pain, diarrhea
Pharmacology
- Half-life: 0.8-11.5h
- Metabolism: Hepatic
- Excretion: Fecal
Mechanism of Action
- Causes parasitic microtubules to degenerate, inhibiting glucose uptake and glycogen storage