Transplant complications: Difference between revisions
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==Types== | ==Types== | ||
*[[Graft-vs-host disease]] | *[[Graft-vs-host disease]] | ||
*[[Stem cell transplant complications]] | |||
*[[Kidney transplant complications]] | *[[Kidney transplant complications]] | ||
*[[Liver transplant complications]] | *[[Liver transplant complications]] | ||
| Line 29: | Line 30: | ||
*[[Pancreas transplant complications]] | *[[Pancreas transplant complications]] | ||
*More severe or opportunistic infections due to immunocompromise | *More severe or opportunistic infections due to immunocompromise | ||
**May be afebrile due to | **May be afebrile due to immunosuppression, have low treshhold for infectious work-up | ||
==See Also== | ==See Also== | ||
Revision as of 02:43, 29 September 2016
Background
- Transplanted (solid) organ frequency: kidney > liver > heart > lung > pancreas > other (combined and intestines)
- Most transplant-related emergencies due to one of the following:
- Infection
- Medication side effect
- Graft-versus-host disease
- Postoperative complications
- Altered physiology due to transplanted organ
Epidemiology
- Types of presentations
- Infection (39%)
- Noninfectious GI/GU pathology (15%)
- Dehydration (15%)
- Electrolyte disturbances (10%)
- Cardiopulmonary pathology (10%)
- Injury (8%)
- Rejection (6%)
- Acute graft-versus-host disease occurs in 20% to 80% of patients post-hematopoietic stem cell transplantation (HSCT); rarely occurs in solid organ transplant [1]
Immunosuppressant Medications
- Balance between immune suppression, rejection and susceptibility to infection
- Typical regimen includes: calcineurin inhibitor + antimetabolite + steroid
- Calcineurin inhibitor
- Steroids
- +/- Antimetabolite
Types
- Graft-vs-host disease
- Stem cell transplant complications
- Kidney transplant complications
- Liver transplant complications
- Heart transplant complications
- Lung transplant complications
- Pancreas transplant complications
- More severe or opportunistic infections due to immunocompromise
- May be afebrile due to immunosuppression, have low treshhold for infectious work-up
See Also
External Links
References
- ↑ Tintinalli's