P450: Difference between revisions
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==Antimicrobials== | ==Antimicrobials== | ||
===Avoid / P450 Inhibitors=== | ===Avoid /[[P450]] Inhibitors=== | ||
*[[Quinolones]], especially [[levofloxacin]] | *[[Quinolones]], especially [[levofloxacin]] | ||
*[[Macrolides]], especially [[erythromycin]] | *[[Macrolides]], especially [[erythromycin]] | ||
| Line 18: | Line 18: | ||
*[[Vancomycin]] | *[[Vancomycin]] | ||
==Significant P450 Inhibitors in General== | ==Significant[[P450]] Inhibitors in General== | ||
*Grapefruit juice | *Grapefruit juice | ||
*Valproate | *Valproate | ||
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*Acute EtOH | *Acute EtOH | ||
==Significant P450 Inducers in General== | ==Significant[[P450]] Inducers in General== | ||
*[[Phenytoin]] | *[[Phenytoin]] | ||
*[[Carbamazepine]] | *[[Carbamazepine]] | ||
Revision as of 17:07, 24 September 2016
Background
Antimicrobials
Avoid /P450 Inhibitors
- Quinolones, especially levofloxacin
- Macrolides, especially erythromycin
- Bactrim and sulfonamides
- Flagyl
- Nafcillin, oxacillin
Use
SignificantP450 Inhibitors in General
- Grapefruit juice
- Valproate
- INH
- Protease inhibitors (-navir, i.e. ritonavir)
- SSRIs, except escitalopram
- Amiodarone
- Fluoroquinolones
- Sulfonamides
- Macrolides
- Cimetidine
- Omeprazole
- Ketoconazole
- Acute EtOH
SignificantP450 Inducers in General
- Phenytoin
- Carbamazepine
- Ethosuximide
- Quinidine/quinine
- Rifampin
- Griseofulvin
- Glucocorticoids
- Barbituates
- St. John's wort
- Chronic EtOH
- Tobacco smoking