ACTH (cosyntropin) stimulation test: Difference between revisions
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==Test== | ==Test== | ||
#Before: Draw serum cortisol | #Before: Draw serum cortisol | ||
#Time 0: Give | #Time 0: Give 0.25mg IM/IV of ACTH (Cosyntropin) over 2min (0.125mg if <2yrs old) | ||
#Time 30: Draw serum cortisol | #Time 30: Draw serum cortisol | ||
#Time 60: Draw serum cortisol & give 100mg hydrodortison IVP | #Time 60: Draw serum cortisol & give 100mg hydrodortison IVP | ||
*'''Normal Response:''' Cortisol level doubles from baseline after Cosyntropin administration | |||
*'''Adrenal Insufficiency:''' Cortisol level fails to rise after Cosyntropin administration | |||
*Normal Response: Cortisol level doubles from baseline after Cosyntropin administration | |||
*Adrenal Insufficiency: Cortisol level fails to rise after Cosyntropin administration | |||
==Management== | ==Management== | ||
* | *If abnormal test, can give: | ||
**[[Dexamethasone]] 6mg IV | **[[Dexamethasone]] 6mg IV '''OR''' [[Hydrocortisone]] 100mg IV | ||
==See Also== | ==See Also== | ||
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==References== | ==References== | ||
<references/> | |||
[[Category:Endocrinology]] | [[Category:Endocrinology]] | ||
Latest revision as of 20:09, 30 May 2017
Background
- ACTH (cosyntropin) stimulation test measures how well the adrenal glands respond to adrenocorticotropic hormone (ACTH)
- ACTH is a hormone produced in the pituitary gland that stimulates the adrenal glands to release a hormone called cortisol
- Man-made form of ACTH is called cosyntropin
Test
- Before: Draw serum cortisol
- Time 0: Give 0.25mg IM/IV of ACTH (Cosyntropin) over 2min (0.125mg if <2yrs old)
- Time 30: Draw serum cortisol
- Time 60: Draw serum cortisol & give 100mg hydrodortison IVP
- Normal Response: Cortisol level doubles from baseline after Cosyntropin administration
- Adrenal Insufficiency: Cortisol level fails to rise after Cosyntropin administration
Management
- If abnormal test, can give:
- Dexamethasone 6mg IV OR Hydrocortisone 100mg IV