Beta-HCG

Chart

Levels over Time

Week	Minimum	Maximum
3	0	5
4	5	426
5	18	7,340
6	1,080	56,500
7-8	7,650	229,000
9-12	25,700	288,000
13-16	13,300	254,000
17-24	4,060	165,400
25-birth	3,640	117,000
4-6 post	NA	<5

Repeat Levels

Repeat B-hCG Levels

Pregnancy Type	B-hCG Change
Normal	Minimum expected rise depends on initial hCG value: Initial hCG <1,500 mIU/mL: minimum 49% rise in 48hrs Initial hCG 1,500-3,000 mIU/mL: minimum 40% rise in 48hrs Initial hCG >3,000 mIU/mL: minimum 33% rise in 48hrs hCG typically doubles approximately every 48-72 hours in early pregnancy Rate of rise slows after hCG reaches approximately 6,000-10,000 mIU/mL
Ectopic	Increases or decreases more slowly than expected ("plateau") Approximately 21% of ectopic pregnancies have a normal hCG rise
Miscarriage	Expected to decline >21-35% in 48 hrs

• A single hCG level cannot reliably distinguish intrauterine from ectopic pregnancy
• The discriminatory zone (typically 1,500-3,500 mIU/mL depending on institution) is the hCG level above which a gestational sac should be visible on transvaginal ultrasound

See Also

• Vaginal Bleeding Pregnant (less than 20wks)
• Ectopic Pregnancy
• Maternal Vitals and Labs in Pregnancy