Fentanyl: Difference between revisions
Neil.m.young (talk | contribs) (Text replacement - "==Sources==" to "==References==") |
(→Special Populations: added) |
||
| Line 16: | Line 16: | ||
*Renal Dosing | *Renal Dosing | ||
**Adult | **Adult | ||
*** Not defined | |||
**Pediatric | **Pediatric | ||
*** Not defined but recommendations for IV: | |||
**** GFR > 50 mL/minute/1.73 m²: no adjustment | |||
**** GFR 10 to 50 mL/minute/1.73 m²: 75% of usual dose | |||
**** GFR < 10 mL/minute/1.73 m²: 50% of usual dose | |||
**** Hemodialysis: 50% of usual dose | |||
*Hepatic Dosing | *Hepatic Dosing | ||
**Adult | **Adult | ||
*** Not defined | |||
**Pediatric | **Pediatric | ||
*** Not defined | |||
==Contraindications== | ==Contraindications== | ||
Revision as of 19:17, 2 April 2019
General
- Type: Opiods
- Dosage Forms: IV, intranasal, transdermal
- Common Trade Names: Sublimaze
Adult Dosing
- Analgesia: 1-2 mcg/kg IV/IM, q30-60 min PRN
- Sedation: 1-3 mcg/kg/hr continuous infusion
Pediatric Dosing
0.5-2 mcg/kg IV q1-2 hr
Special Populations
- Pregnancy Rating: C
- Lactation: Excreted in breast milk, not recommended
- Renal Dosing
- Adult
- Not defined
- Pediatric
- Not defined but recommendations for IV:
- GFR > 50 mL/minute/1.73 m²: no adjustment
- GFR 10 to 50 mL/minute/1.73 m²: 75% of usual dose
- GFR < 10 mL/minute/1.73 m²: 50% of usual dose
- Hemodialysis: 50% of usual dose
- Not defined but recommendations for IV:
- Adult
- Hepatic Dosing
- Adult
- Not defined
- Pediatric
- Not defined
- Adult
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Apnea
Common
- Confusion
- Constipation
- Nausea/Vomiting
- Somnolence
- Sweating
- Asthenia
Pharmacology
- Half-life: 2-4 hours
- Metabolism: Hepatic
- Excretion: Renal
- Mechanism of Action: Narcotic opiate receptor agonist
See Also
References
Micromedex