Vitamin K deficiency: Difference between revisions
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==Background== | ==Background== | ||
*Cofactor for vitamin K-dependent clotting factors II, VII, IX, X | |||
**Used by liver | |||
**Fat soluble | |||
===Causes=== | ===Causes=== | ||
*Nutritional deficiency | |||
*Malabsorption | |||
*Cholestasis: since it is fat soluble and needs bile salts to be absorbed | |||
==Clinical Features== | ==Clinical Features== | ||
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==Treatment== | ==Treatment== | ||
*[[Fresh Frozen Plasma]]: 1ml contains 1U of each clotting factor | |||
*Consider [[Vitamin K]] oral or IV (subcutaneous not recommended): will take up to 24 hours to work and up to 2 weeks to wear off | |||
==Disposition== | ==Disposition== | ||
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*[[Coagulopathy (Main)]] | *[[Coagulopathy (Main)]] | ||
==References== | |||
[[Category:Drugs]] | [[Category:Drugs]] | ||
[[Category:Heme/Onc]] | [[Category:Heme/Onc]] | ||
Revision as of 12:40, 10 June 2015
Background
- Cofactor for vitamin K-dependent clotting factors II, VII, IX, X
- Used by liver
- Fat soluble
Causes
- Nutritional deficiency
- Malabsorption
- Cholestasis: since it is fat soluble and needs bile salts to be absorbed
Clinical Features
Differential Diagnosis
Coagulopathy
Platelet Related
- Too few
- Nonfunctional
Factor Related
- Acquired (Drug Related)
- Warfarin (Coumadin)
- Unfractionated heparin
- Low molecular weight heparin (i.e. enoxaparin (Lovenox), dalteparin)
- Factor Xa Inhibitors (e.g. rivaroxaban, apixaban, fondaparinux, edoxaban)
- Direct thrombin inhibitors (e.g. dabigatran, argatroban, bivalirudin)
- Illness induced
- Genetic
Treatment
- Fresh Frozen Plasma: 1ml contains 1U of each clotting factor
- Consider Vitamin K oral or IV (subcutaneous not recommended): will take up to 24 hours to work and up to 2 weeks to wear off