Acanthosis nigricans: Difference between revisions
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**Lesions in atypical sites such as palms/soles, mucous membranes | **Lesions in atypical sites such as palms/soles, mucous membranes | ||
==Differential Diagnosis== | |||
==Evaluation== | |||
==Management== | |||
==Disposition== | |||
==See Also== | ==See Also== | ||
Revision as of 20:38, 29 March 2023
Background
- Multiple forms, but malignant acanthosis nigricans is most important
- Associated with GI and GU malignancies, which may have concomitant weight loss
- Non malignant form may be associated with endocrine abnormalities, such as insulin resistance
Clinical Features
- Hyperpigmented, velvety
- Plaques
- Most commonly intertriginous areas, posterior neck
- May have concurrent acrochordons, skin tags
Malignant Acanthosis Nigricans[1]
- Associated with other dermal manifestations of internal cancers
- Most commonly associated with colonic adenocarcinoma, gastric cancer, ovarian cancer
- Red flags:
- Up to 50% of malignant acanthosis nigricans have oral involvement
- Rapid appearance of lesions
- Extensive involvement
- Older adult
- Unexplained weight loss
- Lesions in atypical sites such as palms/soles, mucous membranes
Differential Diagnosis
Evaluation
Management
Disposition
See Also
References
- ↑ Miller JH et al. Acanthosis Nigricans Clinical Presentation. eMedicine. Dec 3, 2015. http://emedicine.medscape.com/article/1102488-clinical#showall.
Schwarzenberger K, Callen JP. Chapter 53: Dermatologic manifestations in patients with systemic disease. In: Bolognia JL, Schaffer JV, Cerroni L, eds. Dermatology. 4th ed. Philadelphia, PA: Elsevier; 2017:820.