Baclofen toxicity: Difference between revisions
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==Clinical Features== | ==Clinical Features== | ||
* | *Nausea and vomiting | ||
* | *Drowsziness | ||
*Seizures | *Delirium | ||
* | *Seizures | ||
*Coma | |||
*Respiratory compromise | |||
*Hypothermia | *Hypothermia | ||
Revision as of 21:22, 6 January 2022
Background
- Baclofen is a synthetic derivative of GABA that can be used for conditions such as multiple sclerosis or muscle spasticity
- At therapeutic doses, Baclofen acts as a GABA-B receptor agonist
- At higher doses, Baclofen loses selectivity and can cause sedation
- Primary excreted by the kidneys
Clinical Features
- Nausea and vomiting
- Drowsziness
- Delirium
- Seizures
- Coma
- Respiratory compromise
- Hypothermia
Differential Diagnosis
Sedative/hypnotic toxicity
- Absinthe
- Barbiturates
- Benzodiazepines
- Chloral hydrate
- Gamma hydroxybutyrate (GHB)
- Baclofen toxicity
- Opioids
- Toxic alcohols
- Xylazine toxicity
Evaluation
- Diagnosis of exclusion
Management
- Activated charcoal for recent ingestion
- Supportive care:
- IV fluids, respiratory care
- Vasopressors for persistent hypotension
- Benzodiazepines for seizures
- Hemodialysis for very severe toxicity
Disposition
See Also
References
- Jung, M. “Baclofen Overdoses”. Maryland Poison Center, University of Maryland School of Pharmacy. www.mdpoison.com Accessed April 29th, 2014.
- Nicola Y Leung, Ian M Whyte, Geoffrey K Isbister Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas: 2006, 18(1);77-82