Fidaxomicin: Difference between revisions
ClaireLewis (talk | contribs) |
(Add AntibioticDose SMW query table for dynamic indications by disease) |
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==Adult Dosing== | ==Adult Dosing== | ||
*[[C. diff]] diarrhea: 200mg PO BID x 10d | *[[C. diff]] diarrhea: 200mg PO BID x 10d | ||
===Indications by Disease=== | |||
{{#ask: [[Has DrugName::Fidaxomicin]] [[Has Population::Adult]] | |||
|?Treats disease=Disease | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|format=table | |||
|limit=50 | |||
|mainlabel=- | |||
|headers=show | |||
|sort=Treats disease | |||
}} | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
''Safety/efficacy not established'' | ''Safety/efficacy not established'' | ||
===Indications by Disease=== | |||
{{#ask: [[Has DrugName::Fidaxomicin]] [[Has Population::Pediatric]] | |||
|?Treats disease=Disease | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|format=table | |||
|limit=50 | |||
|mainlabel=- | |||
|headers=show | |||
|sort=Treats disease | |||
}} | |||
==Special Populations== | ==Special Populations== | ||
Latest revision as of 20:38, 20 March 2026
Administration
- Type: Macrolide antibiotic
- Dosage Forms:
- Routes of Administration: PO
- Common Trade Names:
Adult Dosing
- C. diff diarrhea: 200mg PO BID x 10d
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Clostridium difficile | 200 mg PO two times daily for 10 days | Non-Severe |
| Clostridium difficile | 200 mg PO two times daily for 10 days | Severe |
Pediatric Dosing
Safety/efficacy not established
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Clostridium difficile | 200mg PO BID x 10 days (>12yr and >40kg); weight-based for younger | Pediatric Non-Severe (>6 months) |
Special Populations
Pregnancy Rating
- Category B
Lactation risk
- Infant risk cannot be ruled out
Renal Dosing
- No adjustment
Hepatic Dosing
- Not established
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life: ~12h
- Metabolism: Intestinal
- Excretion: Fecal
Mechanism of Action
- Macrolide: inhibits RNA polymerases primarily against clostridia species