Allergic transfusion reaction: Difference between revisions
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==Clinical Features== | ==Clinical Features== | ||
*Symptoms range from urticaria/pruritus to bronchospasm, wheezing, anaphylaxis (rare) | *Symptoms range from [[urticaria]]/[[pruritus]] to bronchospasm, [[wheezing]], [[anaphylaxis]] (rare) | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
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==Evaluation== | ==Evaluation== | ||
*May need to rule out hemolysis - see [[transfusion reaction]] | *May need to rule out [[hemolytic anemia|hemolysis]] - see [[transfusion reaction]] | ||
==Management== | ==Management== | ||
*Stop transfusion until able to evaluate severity of allergic reaction | *Stop transfusion until able to evaluate severity of allergic reaction | ||
*Give [[diphenhydramine]] | *Give [[diphenhydramine]] | ||
**further treatment for [[anaphylaxis]] if needed | |||
*Restart transfusion if symptoms are mild | *Restart transfusion if symptoms are mild | ||
Latest revision as of 23:24, 30 September 2019
Background
- Occurs due to immune response to plasma proteins
- Reaction severity not dose-related
- Most frequently occurs with platelet transfusions
Clinical Features
- Symptoms range from urticaria/pruritus to bronchospasm, wheezing, anaphylaxis (rare)
Differential Diagnosis
Transfusion Reaction Types
- Acute
- Delayed
Acute allergic reaction
- Allergic reaction/urticaria
- Anaphylaxis
- Angioedema
- Anxiety attack
- Asthma exacerbation
- Carcinoid syndrome
- Cold urticaria
- Contrast induced allergic reaction
- Scombroid
- Shock
- Transfusion reaction
Evaluation
- May need to rule out hemolysis - see transfusion reaction
Management
- Stop transfusion until able to evaluate severity of allergic reaction
- Give diphenhydramine
- further treatment for anaphylaxis if needed
- Restart transfusion if symptoms are mild