IV nitroglycerine alternatives: Difference between revisions
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===Nitroglycerine Bioavailability=== | ===Nitroglycerine Bioavailability=== | ||
*Oral <ref>http://sepia.unil.ch/pharmacology/index.php?id=51</ref>: <1% | *Oral <ref name="availability">http://sepia.unil.ch/pharmacology/index.php?id=51</ref>: <1% | ||
*Sublingual <ref | *Sublingual <ref name="availability"/>: 38% (15-40%) | ||
*Topical <ref | *Topical <ref name="availability" />: 72% | ||
Half-life<ref>http://sepia.unil.ch/pharmacology/index.php?id=60</ref>: 0.05 h | Half-life<ref>http://sepia.unil.ch/pharmacology/index.php?id=60</ref>: 0.05 h | ||
Revision as of 00:41, 2 April 2014
Background
- Suggestions for substitution during the IV shortage
Nitroglycerine Bioavailability
Half-life[2]: 0.05 h
Suggested Substitutions[3]
- Sublingual nitroglycerin, 1-2 tabs or sprays every 5 minutes as needed
- Once controlled
- Nitropursside OR Isordil PO (nitro paste or longer acting NTG)
- If not well controlled
- IV enalapril 0.625-1.25mg IV bolus
- IV hydralazine 5-10mg IV bolus
- IV nitropursside
- Once controlled
Source
<references>