Trimethoprim-Sulfamethoxazole DS: Difference between revisions
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**15-20 mg/kg/dy TMP PO divided q6-8h | **15-20 mg/kg/dy TMP PO divided q6-8h | ||
==Special Populations== | |||
*Pregnancy: D | |||
*Lactation: ? | |||
*Renal (Adult & Pediatric) | |||
**CrCl 15-30: Decrease dose by 50% | |||
**CrCl <15: Avoid use | |||
**Hemodialysis: Give supplement | |||
**Peritoneal Dialysis: No supplement | |||
*Hepatic (Adult & Pediatric) | |||
**Mild-mod impairment: Caution advised | |||
**Significant impairment: Contraindicated | |||
==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
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*Excretion: | *Excretion: | ||
*Mechanism of Action: Bactericidal | *Mechanism of Action: Bactericidal | ||
==See Also== | ==See Also== | ||
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==Source== | ==Source== | ||
*Epocrates | |||
[[Category:Drugs]] | [[Category:Drugs]] | ||
Revision as of 22:24, 27 February 2014
General
- Type: Sulfonamide
- Dosage Forms: 160/800
- Common Trade Names: Bactrim DS
- Abbreviations: TMP-SMX, TMP-SMZ
Adult Dosing
General
1 tab (160mg TMP) PO Q12h
PCP Prophylaxis
80-160mg TMP PO daily
PCP Treatment
15-20 mg/kg/day TMP PO divided q6-8h x 21 days
Pediatric Dosing
General (>2mo)
- Mild-mod infection
- 4-5 mg/kg TMP PO q12hr
- Severe infection
- 15-20 mg/kg/dy TMP PO divided q6-8h
Special Populations
- Pregnancy: D
- Lactation: ?
- Renal (Adult & Pediatric)
- CrCl 15-30: Decrease dose by 50%
- CrCl <15: Avoid use
- Hemodialysis: Give supplement
- Peritoneal Dialysis: No supplement
- Hepatic (Adult & Pediatric)
- Mild-mod impairment: Caution advised
- Significant impairment: Contraindicated
Contraindications
- Allergy to class/drug
- <2 months of age (except as PCP prophylaxis)
- Significant hepatic impairment
- Megaloblastic anemia or folate deficiency
- G6PD deficiency
Adverse Reactions
Serious
- Stevens-Johnson Syndrome
- Toxic Epidermal Necrolysis
- Fulminant hepatic necrosis
- Agranulocytosis
- Aplastic anemia
- Blood dyscrasias
- Thrombocytopenia
- Hypersensitivity Reaction
- Photosensitivity
- Hepatotoxicity
- Pancreatitis
- Intersitial nephritis
- Renal Failure
- Pulmonary infiltrates
- Myelosuppression
- Methhemoglobinemia
- Hyperkalemia
- Hyponatremia
- Aseptic meningitis
- Seizures
- Lupus Erythematosus
- Hypoglycemia
- Clostridium difficile
- Rhabdomyolysis
- Congenital malformations
- Congenital neural tube defects
- Kernicterus (neonates)
Common
- Nausea and Vomiting
- Anorexia
- Rash
- Urticaria
- Hypersensitivity Reaction
- Photosensitivity
- Diarrhea
- Dizziness
- Dyspepsia
- Headache
- Lethargy
Pharmacology
- Half-life: 6-12h (20-50h ESRD)
- Metabolism:
- Excretion:
- Mechanism of Action: Bactericidal
See Also
Source
- Epocrates