Tamsulosin: Difference between revisions
Neil.m.young (talk | contribs) (Text replacement - "Alpha" to "α") |
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==Administration== | ==Administration== | ||
*Type: | *Type: α blocker | ||
*Dosage Forms: | *Dosage Forms: | ||
*Routes of Administration: oral | *Routes of Administration: oral | ||
| Line 39: | Line 39: | ||
==Mechanism of Action== | ==Mechanism of Action== | ||
* | *α-1A antagonist→ smooth muscle relaxation in bladder neck, prostate, urethra→ increased urine flow rate | ||
==Comments== | ==Comments== | ||
==See Also== | ==See Also== | ||
*[[EBQ: | *[[EBQ:α-blockers for ureteral stone expulsion]] | ||
*[[Urolithiasis]] | *[[Urolithiasis]] | ||
Revision as of 01:12, 24 July 2017
Administration
- Type: α blocker
- Dosage Forms:
- Routes of Administration: oral
- Common Trade Names: Flomax
Adult Dosing
- 0.4mg PO once daily or nightly
Urolithiasis
- 0.4mg PO QHS until stone expulsion
Pediatric Dosing
Safety/efficacy not established
Special Populations
- Pregnancy Rating: B
- Lactation risk: Infant risk cannot be ruled out
Renal Dosing
- Adult: No adjustment for CrCl >10
Hepatic Dosing
- Adult: No adjustment
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Retinal detachment
- Priapism
Common
- Headache, dizziness, insomnia, somnolence
- Abnormal ejaculation
- Rhinitis
- Back pain
Pharmacology
- Half-life: 9-15h
- Metabolism: CYP3A4 and CYP2D6
- Excretion: Mostly renal
Mechanism of Action
- α-1A antagonist→ smooth muscle relaxation in bladder neck, prostate, urethra→ increased urine flow rate