Bisacodyl: Difference between revisions
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==Administration== | ==Administration== | ||
*Type: laxative | *Type: [[laxative]] | ||
*Dosage Forms: | *Dosage Forms: tablet, enema, suppository | ||
*Routes of Administration: | *Dosage Strengths: tablet: 5mg; enema: 10mg/30mL; suppository: 10mg | ||
*Common Trade Names: | *Routes of Administration: PO, PR | ||
*Common Trade Names: Dulcolax, Correctol, BisacEvac, Bisacolax, Codulax, Alophen, Feen A Mint, Fleet Stimulant Laxative, Laxit, Modane | |||
==Adult Dosing== | ==Adult Dosing== | ||
| Line 32: | Line 33: | ||
*Abdominal discomfort/colic, diarrhea, proctitis (with suppository use) | *Abdominal discomfort/colic, diarrhea, proctitis (with suppository use) | ||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 8 hr | ||
*Metabolism: | *Metabolism: Metabolized to BHPM in the colon | ||
*Excretion: | *Excretion: Urine and bile | ||
==Mechanism of Action== | ==Mechanism of Action== | ||
| Line 43: | Line 44: | ||
*[[Constipation]] | *[[Constipation]] | ||
==References== | ==References== | ||
*Ahlfors CE. Benzyl alcohol, kernicterus, and unbound bilirubin. J Pediatr. 2001;139(2):317-319. [PubMed 11487763] | |||
*Centers for Disease Control (CDC). Neonatal deaths associated with use of benzyl alcohol—United States. MMWR Morb Mortal Wkly Rep. 1982;31(22):290-291. http://www.cdc.gov/mmwr/preview/mmwrhtml/00001109.htm [PubMed 6810084] | |||
*Christie J, Rose S. Constipation, diarrhea, hemorrhoids, and fecal incontinence. In: Pregnancy in gastrointestinal disorders. Bethesda (MD): ACG Monograph American College of Physicians; 2007. p. 4–9. Available at https://www.acg.gi.org | |||
*Ducodyl (bisacodyl) [prescribing information]. Troy, MI: Prime Marketing; received January 2019. | |||
*Friedrich C, Richter E, Trommeshauser D, et al, "Absence of Excretion of the Active Moiety of Bisacodyl and Sodium Picosulfate Into Human Breast Milk: An Open-Label, Parallel-Group, Multiple-Dose Study in Healthy Lactating Women," Drug Metab Pharmacokinet, 2011, 26(5):458-64. [PubMed 21697613] | |||
*"Inactive" ingredients in pharmaceutical products: update (subject review). Pediatrics.1997;99(2):268-278. [PubMed 9024461] | |||
*Tabbers MM, DiLorenzo C, Berger MY, et al. Evaluation and treatment of functional constipation in infants and children: evidence-based recommendations from ESPGHAN and NASPGHAN. J Pediatr Gastroenterol Nutr. 2014;58(2):258-274. [PubMed 24345831] | |||
<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] [[Category:GI]] | ||
Latest revision as of 21:35, 19 September 2019
Administration
- Type: laxative
- Dosage Forms: tablet, enema, suppository
- Dosage Strengths: tablet: 5mg; enema: 10mg/30mL; suppository: 10mg
- Routes of Administration: PO, PR
- Common Trade Names: Dulcolax, Correctol, BisacEvac, Bisacolax, Codulax, Alophen, Feen A Mint, Fleet Stimulant Laxative, Laxit, Modane
Adult Dosing
- 5-30mg PO daily
- 10mg suppository daily
Pediatric Dosing
- 6-11 yrs: 5mg or rectally daily
Special Populations
- Pregnancy Rating: A
- Lactation risk: infant risk cannot be ruled out
Renal Dosing
- Adult:
- Pediatric:
Hepatic Dosing
- Adult:
- Pediatric:
Contraindications
- Allergy to class/drug
- Appendicitis
- Bowel obstruction
- Gastroenteritis
Adverse Reactions
Serious
- Colonic atony
Common
- Abdominal discomfort/colic, diarrhea, proctitis (with suppository use)
Pharmacology
- Half-life: 8 hr
- Metabolism: Metabolized to BHPM in the colon
- Excretion: Urine and bile
Mechanism of Action
- Stimulates peristalsis via parasympathetic reflexes
Comments
See Also
References
- Ahlfors CE. Benzyl alcohol, kernicterus, and unbound bilirubin. J Pediatr. 2001;139(2):317-319. [PubMed 11487763]
- Centers for Disease Control (CDC). Neonatal deaths associated with use of benzyl alcohol—United States. MMWR Morb Mortal Wkly Rep. 1982;31(22):290-291. http://www.cdc.gov/mmwr/preview/mmwrhtml/00001109.htm [PubMed 6810084]
- Christie J, Rose S. Constipation, diarrhea, hemorrhoids, and fecal incontinence. In: Pregnancy in gastrointestinal disorders. Bethesda (MD): ACG Monograph American College of Physicians; 2007. p. 4–9. Available at https://www.acg.gi.org
- Ducodyl (bisacodyl) [prescribing information]. Troy, MI: Prime Marketing; received January 2019.
- Friedrich C, Richter E, Trommeshauser D, et al, "Absence of Excretion of the Active Moiety of Bisacodyl and Sodium Picosulfate Into Human Breast Milk: An Open-Label, Parallel-Group, Multiple-Dose Study in Healthy Lactating Women," Drug Metab Pharmacokinet, 2011, 26(5):458-64. [PubMed 21697613]
- "Inactive" ingredients in pharmaceutical products: update (subject review). Pediatrics.1997;99(2):268-278. [PubMed 9024461]
- Tabbers MM, DiLorenzo C, Berger MY, et al. Evaluation and treatment of functional constipation in infants and children: evidence-based recommendations from ESPGHAN and NASPGHAN. J Pediatr Gastroenterol Nutr. 2014;58(2):258-274. [PubMed 24345831]