Cephalosporins: Difference between revisions

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==1st Generation==
==1st Generation==
* Skin and soft tissue infections (why is agent of choice before gen sx)
*Skin and soft tissue infections (why is agent of choice before generalized symptoms)
* [[Ceftriaxone_Cross-reactivity|Cross-reactivity of PCN]] allergy <10%
*[[EBQ:Cephalosporin Cross-reactivity|Cross-reactivity of PCN]] allergy <10%


==2nd Generation==
==2nd Generation==
* Intestinal [[anaerobes]] (why is agent of choice for colorectal sx)
*Intestinal [[anaerobes]] (why is agent of choice for colorectal sx)
* Largely displaced by 3rd gen agents
*Largely displaced by 3rd gen agents


==3rd Generation==
==3rd Generation==
* Drug of choice for serious infections due to:
*Drug of choice for serious infections due to:
** Klebsiella
**[[Klebsiella]]
** Enterobacter
**[[Enterobacter]]
** Proteus
**Proteus
** Haemophilus
**[[Haemophilus]]
* [[Gonorrhea]]
*[[Gonorrhea]]
* [[Lyme Disease]]
*[[Lyme Disease]]
* [[Meningitis]] (+ [[vanc]] and [[ampicillin]])
*[[Meningitis]] (+ [[vanc]] and [[ampicillin]])
* Pseudomonas meningitis (+ AG)
*[[Pseudomonas]] meningitis (+ AG)


==4th Generation==
==4th Generation==
* Resistant, nosocomial infections
*Resistant, nosocomial infections


{{Template:Clinically Utilized Antibiotics}}
{{Clinically Utilized Antibiotics}}


==See Also==
==See Also==

Latest revision as of 01:29, 21 February 2021

1st Generation

  • Skin and soft tissue infections (why is agent of choice before generalized symptoms)
  • Cross-reactivity of PCN allergy <10%

2nd Generation

  • Intestinal anaerobes (why is agent of choice for colorectal sx)
  • Largely displaced by 3rd gen agents

3rd Generation

4th Generation

  • Resistant, nosocomial infections

See Also

References

Goodman & Gilman's Pharmacology