Ibutilide: Difference between revisions
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== Adult Dosing == | ==General== | ||
*Type: [[Antiarrhythmics]] | |||
*Dosage Forms:IV 1mg/10mL | |||
*Common Trade Names: Corvert | |||
==Adult Dosing== | |||
*Loading dose = 1mg IV in 50mL D5W over 10min (wt>60kg) | *Loading dose = 1mg IV in 50mL D5W over 10min (wt>60kg) | ||
*Loading dose = 0.01mg/kg IV in 50mL D5W over 10min (wt<60kg) | *Loading dose = 0.01mg/kg IV in 50mL D5W over 10min (wt<60kg) | ||
*Dose may be repeated 10min after completion of 1st dose | *Dose may be repeated 10min after completion of 1st dose | ||
== | ==Pediatric Dosing== | ||
''Safety/efficacy not established'' | |||
==Special Populations== | |||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: Use in pregnancy may be considered, but data is sparse | |||
*[[Lactation risk categories|Lactation risk]]: Not recoemmended | |||
*Renal Dosing: none | |||
*Hepatic Dosing: none | |||
== Indications == | ==Indications== | ||
*Rapid conversion of recent-onset A-fib/flutter to NSR | *Rapid conversion of recent-onset A-fib/flutter to NSR | ||
== | ==Contraindications== | ||
* | *Allergy to class/drug | ||
== Adverse | ==Adverse Reactions== | ||
*QT prolongation, V-tach, torsades | *QT prolongation, V-tach, torsades | ||
*Observe for 4hr after infusion | *Observe for 4hr after infusion | ||
== Kinetics == | ==Pharmacology== | ||
*Half-life: 2-12h | |||
*Metabolism: Hepatic | |||
*Excretion: Mostly urine | |||
*Mechanism of Action: Class III - Prolongs AP and refractory period | |||
===Kinetics=== | |||
*Onset of action = 20-30min | *Onset of action = 20-30min | ||
*Duration of action = 24hr | *Duration of action = 24hr | ||
==Comments== | |||
==See Also== | ==See Also== | ||
[[Antiarrhythmics]] | *[[Antiarrhythmics]] | ||
[[Category: | ==References== | ||
<references/> | |||
[[Category:Pharmacology]] [[Category:Cardiology]] | |||
Latest revision as of 20:30, 22 September 2019
General
- Type: Antiarrhythmics
- Dosage Forms:IV 1mg/10mL
- Common Trade Names: Corvert
Adult Dosing
- Loading dose = 1mg IV in 50mL D5W over 10min (wt>60kg)
- Loading dose = 0.01mg/kg IV in 50mL D5W over 10min (wt<60kg)
- Dose may be repeated 10min after completion of 1st dose
Pediatric Dosing
Safety/efficacy not established
Special Populations
- Pregnancy Rating: Use in pregnancy may be considered, but data is sparse
- Lactation risk: Not recoemmended
- Renal Dosing: none
- Hepatic Dosing: none
Indications
- Rapid conversion of recent-onset A-fib/flutter to NSR
Contraindications
- Allergy to class/drug
Adverse Reactions
- QT prolongation, V-tach, torsades
- Observe for 4hr after infusion
Pharmacology
- Half-life: 2-12h
- Metabolism: Hepatic
- Excretion: Mostly urine
- Mechanism of Action: Class III - Prolongs AP and refractory period
Kinetics
- Onset of action = 20-30min
- Duration of action = 24hr