Cannabinoid hyperemesis syndrome: Difference between revisions

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==Background==
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Cannabis is the most widely used drug in the US and the world.  The syndrome, first described by Allen et al. in 2004 consists of nausea, vomiting, and abdominal pain in a patient with no other organic cause who frequently uses marijuana and has relief of symptoms with hot showers<ref> Allen, J H; De Moore, GM; Heddle, R; Twartz, JC (2004). "Cannabinoid hyperemesis: Cyclical hyperemesis in association with chronic cannabis abuse". Gut 53 (11): 1566–70. doi:10.1136/gut.2003.036350. PMC 1774264</ref>
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===Current Controversies===
==Background== <!--T:1-->
*The pathophysiology and exact cause of the syndrome remains under question, especially since cannabis acts as an antiemetic <ref>Byrne, A; Hallinan, R; Wodak, A (2006). "'Cannabis hyperemesis' causation questioned". Gut 55 (1): 132; author reply 132. PMC 1856368</ref>


==Clinical Features<ref>Simonetto, Douglas A.; Oxentenko, Amy S.; Herman, Margot L.; Szostek, Jason H. (2012). "Cannabinoid Hyperemesis: A Case Series of 98 Patients". Mayo Clinic Proceedings 87 (2): 114–9. doi:10.1016/j.mayocp.2011.10.005. PMID 22305024</ref>==
<!--T:2-->
Essential Features<br />
*Cannabis is the most widely used drug in the US and the world
* Long term cannabis use (typically > 2years)
*Cannabinoid hyperemesis syndrome, first described by Allen et al. in 2004 consists of nausea, vomiting, and abdominal pain in a patient with no other organic cause who frequently uses marijuana and has relief of symptoms with hot showers<ref> Allen, J H; De Moore, GM; Heddle, R; Twartz, JC (2004). "Cannabinoid hyperemesis: Cyclical hyperemesis in association with chronic cannabis abuse". Gut 53 (11): 1566–70. doi:10.1136/gut.2003.036350. PMC 1774264</ref>
Major Features<br />
*Pathophysiology not yet well understood<ref>Byrne, A; Hallinan, R; Wodak, A (2006). "'Cannabis hyperemesis' causation questioned". Gut 55 (1): 132; author reply 132. PMC 1856368</ref>
* severe cyclical nausea, vomiting
* weekly use of marijuana
* relief of symptoms with hot showers or baths
* abdominal pain: epigastric or periumbilical
* resolution of symptoms with cannabis cessation
Supportive Features
* Age < 50y
* Weight loss > 5kg
* Symptoms greater in morning
* Normal bowel habits
* Negative labs, imaging and endoscopy


==Differential Diagnosis==
 
==Clinical Features<ref>Simonetto, Douglas A.; Oxentenko, Amy S.; Herman, Margot L.; Szostek, Jason H. (2012). "Cannabinoid Hyperemesis: A Case Series of 98 Patients". Mayo Clinic Proceedings 87 (2): 114–9. doi:10.1016/j.mayocp.2011.10.005. PMID 22305024</ref>== <!--T:3-->
 
 
===Essential Features=== <!--T:4-->
 
<!--T:5-->
*Long term cannabis use (typically > 2 years)
 
 
===Major Features=== <!--T:6-->
 
<!--T:7-->
*Severe cyclical [[Special:MyLanguage/nausea|nausea]], [[Special:MyLanguage/vomiting |vomiting ]]
*Weekly use of [[Special:MyLanguage/marijuana|marijuana]]
*Relief of symptoms with hot showers or baths
*[[Special:MyLanguage/Abdominal pain|Abdominal pain]]: epigastric or periumbilical
*Resolution of symptoms with cannabis cessation
 
 
===Supportive Features=== <!--T:8-->
 
<!--T:9-->
*Age < 50y
*Weight loss > 5kg
*Symptoms greater in morning
*Normal bowel habits
*Negative labs, imaging and endoscopy
 
 
==Differential Diagnosis== <!--T:10-->
 
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{{Nausea and vomiting DDX}}
{{Nausea and vomiting DDX}}
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==Diagnosis==
Diagnosis of exclusion after complete workup for [[Nausea and Vomiting]]


==Management==
==Evaluation== <!--T:11-->
*Symptomatic treatment: [[Antiemetics]], Anxiolytics, and Hydration<br />
*Cessation of marijuana use
*Capsaicin Cream


==Disposition==
<!--T:12-->
Home once [[nausea and vomiting]] is controlled
*Generally considered a diagnosis of exclusion after evaluating for other causes of [[Special:MyLanguage/nausea and vomiting|nausea and vomiting]]


==External Links==
 
*[http://lifeinthefastlane.com/therapeutic-showering/ LITFL: Therapeutic Showering]
==Management== <!--T:13-->
 
<!--T:14-->
*Cessation of marijuana use, as hyperemetic phase lasts only 24-48 hrs unless pt relapses
*Symptomatic treatment ([[Special:MyLanguage/Antiemetics|Antiemetics]], anxiolytics, and hydration)
**[[Special:MyLanguage/Haloperidol|Haloperidol]] 5 mg IV/IM and [[Special:MyLanguage/diphenhydramine|diphenhydramine]] 50 mg IV<ref>Hickey JL et al. Haloperidol for treatment of cannabinoid hyperemesis syndrome. Am J Emerg Med. 2013 Jun;31(6):1003.e5-6.</ref>
**Hot shower (>109°F), though short-lived<ref>Galli JA et al. Cannabinoid Hyperemesis Syndrome. Curr Drug Abuse Rev. 2011 Dec; 4(4): 241–249.</ref>
**[[Special:MyLanguage/Capsaicin|Capsaicin]] cream 0.025-0.075% across abdomen/arms/back, with symptoms diminishing within 30 min<ref>Leon G. Toxicology Rounds: The Anti-Munchies: Cannabinoid Hyperemesis Syndrome. Emergency Medicine News: November 2011 - Volume 33 - Issue 11 - p 14.</ref>
**[[Special:MyLanguage/Lorazepam|Lorazepam]] 1-2 mg IV <ref>Smith TN, et al. Cannabinoid hyperemesis syndrome: an unrecognized cause of nausea and vomiting. JAAPA. 2019.  Apr;32(4):1-5 </ref>
 
 
==Disposition== <!--T:15-->
 
<!--T:16-->
*Discharge once tolerating PO
 
 
==See Also== <!--T:17-->
 
<!--T:18-->
*[[Special:MyLanguage/Nausea and vomiting|Nausea and vomiting]]
*[[Special:MyLanguage/Marijuana|Marijuana]]
 
 
==External Links== <!--T:19-->
 
<!--T:20-->
*[http://lifeinthefastlane.com/therapeutic-showering/ LITFL:Therapeutic Showering]
*[http://www.thepoisonreview.com/2014/07/16/review-of-cannabinoid-hyperemesis-syndrome/ The Poison Review: Review of cannabinoid hyperemesis syndrome]
*[http://www.thepoisonreview.com/2014/07/16/review-of-cannabinoid-hyperemesis-syndrome/ The Poison Review: Review of cannabinoid hyperemesis syndrome]


==See Also==
[[Nausea and Vomiting]]


==References==
==References== <!--T:21-->
 
<!--T:22-->
<references/>
<references/>


[[Category:Tox]]
<!--T:23-->
[[Category:Toxicology]]
[[Category:GI]]
[[Category:GI]]
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Latest revision as of 12:26, 7 January 2026

Other languages:

Background

  • Cannabis is the most widely used drug in the US and the world
  • Cannabinoid hyperemesis syndrome, first described by Allen et al. in 2004 consists of nausea, vomiting, and abdominal pain in a patient with no other organic cause who frequently uses marijuana and has relief of symptoms with hot showers[1]
  • Pathophysiology not yet well understood[2]


Clinical Features[3]

Essential Features

  • Long term cannabis use (typically > 2 years)


Major Features

  • Severe cyclical nausea, vomiting
  • Weekly use of marijuana
  • Relief of symptoms with hot showers or baths
  • Abdominal pain: epigastric or periumbilical
  • Resolution of symptoms with cannabis cessation


Supportive Features

  • Age < 50y
  • Weight loss > 5kg
  • Symptoms greater in morning
  • Normal bowel habits
  • Negative labs, imaging and endoscopy


Differential Diagnosis

Nausea and vomiting

Critical

Emergent

Nonemergent


Evaluation

  • Generally considered a diagnosis of exclusion after evaluating for other causes of nausea and vomiting


Management

  • Cessation of marijuana use, as hyperemetic phase lasts only 24-48 hrs unless pt relapses
  • Symptomatic treatment (Antiemetics, anxiolytics, and hydration)


Disposition

  • Discharge once tolerating PO


See Also


External Links


References

  1. ↑ Allen, J H; De Moore, GM; Heddle, R; Twartz, JC (2004). "Cannabinoid hyperemesis: Cyclical hyperemesis in association with chronic cannabis abuse". Gut 53 (11): 1566–70. doi:10.1136/gut.2003.036350. PMC 1774264
  2. ↑ Byrne, A; Hallinan, R; Wodak, A (2006). "'Cannabis hyperemesis' causation questioned". Gut 55 (1): 132; author reply 132. PMC 1856368
  3. ↑ Simonetto, Douglas A.; Oxentenko, Amy S.; Herman, Margot L.; Szostek, Jason H. (2012). "Cannabinoid Hyperemesis: A Case Series of 98 Patients". Mayo Clinic Proceedings 87 (2): 114–9. doi:10.1016/j.mayocp.2011.10.005. PMID 22305024
  4. ↑ Hickey JL et al. Haloperidol for treatment of cannabinoid hyperemesis syndrome. Am J Emerg Med. 2013 Jun;31(6):1003.e5-6.
  5. ↑ Galli JA et al. Cannabinoid Hyperemesis Syndrome. Curr Drug Abuse Rev. 2011 Dec; 4(4): 241–249.
  6. ↑ Leon G. Toxicology Rounds: The Anti-Munchies: Cannabinoid Hyperemesis Syndrome. Emergency Medicine News: November 2011 - Volume 33 - Issue 11 - p 14.
  7. ↑ Smith TN, et al. Cannabinoid hyperemesis syndrome: an unrecognized cause of nausea and vomiting. JAAPA. 2019. Apr;32(4):1-5
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