Template:PCP pneumonia antibiotics: Difference between revisions
(Convert to AntibioticDose with disease=Pneumocystis jirovecii pneumonia for SMW linking) |
(Add pediatric treatment and prophylaxis dosing) |
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====Prophylaxis==== | ====Prophylaxis==== | ||
*{{AntibioticDose|disease=Pneumocystis jirovecii pneumonia|drug=Trimethoprim-Sulfamethoxazole DS|dose=1 DS tablet daily|context=Prophylaxis|display=TMP/SMX|population=Adult}}, but one single strength tablet daily or one double-strength three times weekly is acceptable.<ref>CDC Guidelines for Prophylaxis Against Pneumocystis carinii Pneumonia for Children Infected with Human Immunodeficiency Virus http://www.cdc.gov/mmwr/preview/mmwrhtml/00001957.htm</ref> | *{{AntibioticDose|disease=Pneumocystis jirovecii pneumonia|drug=Trimethoprim-Sulfamethoxazole DS|dose=1 DS tablet daily|context=Prophylaxis|display=TMP/SMX|population=Adult}}, but one single strength tablet daily or one double-strength three times weekly is acceptable.<ref>CDC Guidelines for Prophylaxis Against Pneumocystis carinii Pneumonia for Children Infected with Human Immunodeficiency Virus http://www.cdc.gov/mmwr/preview/mmwrhtml/00001957.htm</ref> | ||
====Pediatric Treatment==== | |||
*{{AntibioticDose|disease=Pneumocystis jirovecii pneumonia|drug=Trimethoprim-Sulfamethoxazole DS|display=TMP/SMX|dose=5mg/kg (TMP) IV/PO q6-8hrs x 21 days|context=Pediatric Treatment|population=Pediatric}} | |||
*{{AntibioticDose|disease=Pneumocystis jirovecii pneumonia|drug=Pentamidine|dose=4mg/kg IV daily x 21 days|context=Pediatric Severe, TMP/SMX intolerant|population=Pediatric}} if TMP/SMX intolerant | |||
*{{AntibioticDose|disease=Pneumocystis jirovecii pneumonia|drug=Dapsone|dose=2mg/kg/day PO (max 100mg)|context=Pediatric Mild|population=Pediatric}} + TMP 15mg/kg/day PO divided TID for mild disease | |||
====Pediatric Prophylaxis==== | |||
*{{AntibioticDose|disease=Pneumocystis jirovecii pneumonia|drug=Trimethoprim-Sulfamethoxazole DS|display=TMP/SMX|dose=5mg/kg/day (TMP) PO divided BID 3 days/week|context=Pediatric Prophylaxis|population=Pediatric}} (first line) | |||
*{{AntibioticDose|disease=Pneumocystis jirovecii pneumonia|drug=Dapsone|dose=2mg/kg/day PO daily (max 100mg)|context=Pediatric Prophylaxis alt|population=Pediatric}} or [[Atovaquone]] as alternatives | |||
Latest revision as of 13:14, 20 March 2026
Mild Disease
- TMP/SMX 2 DS tablets PO q8hrs OR
- High incidence of allergy in HIV
- Dapsone 100mg PO once daily + TMP 5mg/kg PO q8hrs OR
- caution: dapsone can cause methemoglobinemia
- Atavaquone 750mg PO q12hrs OR
- Primaquine 30mg PO q24hrs + Clindamycin 450mg PO q8hrs
Severe Disease
- TMP/SMX 5mg/kg IV q8hrs x 21 days OR
- Pentamidine 4mg/kg IV daily over 60 min OR
- Watch for side effects of hypoglycemia and hypotension
- Primaquine 30mg PO once daily + Clindamycin 900mg IV q8hrs
Prophylaxis
- TMP/SMX 1 DS tablet daily, but one single strength tablet daily or one double-strength three times weekly is acceptable.[1]
Pediatric Treatment
- TMP/SMX 5mg/kg (TMP) IV/PO q6-8hrs x 21 days
- Pentamidine 4mg/kg IV daily x 21 days if TMP/SMX intolerant
- Dapsone 2mg/kg/day PO (max 100mg) + TMP 15mg/kg/day PO divided TID for mild disease
Pediatric Prophylaxis
- TMP/SMX 5mg/kg/day (TMP) PO divided BID 3 days/week (first line)
- Dapsone 2mg/kg/day PO daily (max 100mg) or Atovaquone as alternatives
- ↑ CDC Guidelines for Prophylaxis Against Pneumocystis carinii Pneumonia for Children Infected with Human Immunodeficiency Virus http://www.cdc.gov/mmwr/preview/mmwrhtml/00001957.htm