Ceftaroline fosamil: Difference between revisions
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==General== | ==General== | ||
*Type: 5th | *Type: [[Is Generation::5th generation]] [[Is DrugClass::Cephalosporin]] | ||
*Dosage Forms: IV | *Dosage Forms: injectable, powder for reconstitution | ||
*Common Trade Names: | *Dosage Strengths: 400mg/vial, 600mg/vial | ||
*Routes of Administration: IV | |||
*Common Trade Names: Teflaro | |||
==Adult Dosing== | ==Adult Dosing== | ||
===[[Pneumonia (Main)|Community Acquired Pneumonia]]=== | ===[[Pneumonia (Main)|Community Acquired Pneumonia]]=== | ||
* | *600mg IV q12h x5-7 days | ||
===[[Cellulitis]]=== | ===[[Cellulitis]]=== | ||
* | *600mg IV q12h x5-14 days | ||
===Renal Dosing=== | ===Renal Dosing=== | ||
*CrCl 30-50: | *CrCl 30-50: 400mg q12h; CrCl 15-30: 300mg q12h; ESRD/HD: 200mg q12h | ||
===Hepatic Dosing=== | ===Hepatic Dosing=== | ||
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*Lactation: Safety Unknown | *Lactation: Safety Unknown | ||
*Renal Dosing | *Renal Dosing | ||
**Adult: CrCl 30-50: | **Adult: CrCl 30-50: 400mg q12h; CrCl 15-30: 300mg q12h; ESRD/HD: 200mg q12h | ||
**Pediatric: Drug not available for pediatrics | **Pediatric: Drug not available for pediatrics | ||
*Hepatic Dosing | *Hepatic Dosing | ||
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*[[Antibiotics (Main)]] | *[[Antibiotics (Main)]] | ||
== | ==References== | ||
<references/> | <references/> | ||
[[Category: | [[Category:Pharmacology]] [[Category:ID]] | ||
Latest revision as of 16:22, 18 July 2025
General
- Type: 5th generation Cephalosporin
- Dosage Forms: injectable, powder for reconstitution
- Dosage Strengths: 400mg/vial, 600mg/vial
- Routes of Administration: IV
- Common Trade Names: Teflaro
Adult Dosing
Community Acquired Pneumonia
- 600mg IV q12h x5-7 days
Cellulitis
- 600mg IV q12h x5-14 days
Renal Dosing
- CrCl 30-50: 400mg q12h; CrCl 15-30: 300mg q12h; ESRD/HD: 200mg q12h
Hepatic Dosing
- No adjustment
Pediatric Dosing
- Currently no pediatric dosing for this drug.
Special Populations
- Pregnancy Rating:B
- Lactation: Safety Unknown
- Renal Dosing
- Adult: CrCl 30-50: 400mg q12h; CrCl 15-30: 300mg q12h; ESRD/HD: 200mg q12h
- Pediatric: Drug not available for pediatrics
- Hepatic Dosing
- Adult: No Adjustment
- Pediatric: NA
Contraindications
- Allergy to class/drug (see also Cephalosporin Cross-reactivity)
- Caution if hypersensitive to beta-lactams
- Caution if recent antibiotic-associated colitis history
Adverse Reactions
Serious
- Anaphylaxis
- Hypersensitivity Reaction
- Clostridium difficile associated diarrhea
- SUPERINFECTION
- Hemolytic Anemia
Common
- Diarrhea
- Nausea
- Rash
- Constipation
- Vomiting
- ALT, AST elevated
- Hypokalemia
- Phlebitis
Pharmacology
- Half-life: 2.6 Hours
- Metabolism: Hydrolysis; CYP450: none; prodrug converted to ceftaroline
- Excretion: Urine primarily
- Mechanism of Action: Bactericidal, inhibits cell wall mucopeptide synthesis