Lorazepam: Difference between revisions
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==General== | ==General== | ||
*Type: [[Benzodiazepine]] | *Type: [[Is DrugClass::Benzodiazepine]] | ||
*Dosage Forms: | *Dosage Forms: Tablet: [[Has Dose::0.5]], [[Has Dose::1]], [[Has Dose::2]] [[Has Unit::mg]]. IV solution: 2mg/ml, 4 mg/ml | ||
*Common Trade Names: Ativan | *Common Trade Names: [[BrandName::Ativan]] | ||
==Adult Dosing== | ==Adult Dosing== | ||
*Active [[Seizure]] | *Active [[Has Indication::Seizure]] | ||
**2mg IV or IM | **[[SeizureDose::2mg IV or IM]] | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
Seizure | |||
* 0.1 mg/kg IV | |||
==Special Populations== | ==Special Populations<ref>Lorazepam: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019. </ref>== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | ||
*Lactation: | *Lactation: | ||
** Lorazepam is present in breast milk | |||
*Renal Dosing | *Renal Dosing | ||
**Adult | **Adult | ||
*** PO: no adjustment necessary | |||
*** IV: | |||
**** Mild to moderate impairment | |||
***** No adjustment necessary | |||
**** Severe impairment | |||
***** Use not recommended | |||
**Pediatric | **Pediatric | ||
*** PO: not defined | |||
*** IV: | |||
**** Mild to moderate impairment | |||
***** No adjustment necessary | |||
**** Severe impairment | |||
***** Use not recommended | |||
*Hepatic Dosing | *Hepatic Dosing | ||
**Adult | **Adult | ||
*** PO: | |||
**** Mild to moderate impairment: No adjustment necessary | |||
**** Severe impairment: May need lower doses, use caution | |||
*** IV: | |||
**** Mild to moderate impairment: No adjustment necessary | |||
**** Severe impairment: Use not recommended | |||
**Pediatric | **Pediatric | ||
*** ≥ 12 years old: No adjustment necessary however use caution with severe hepatic disease | |||
==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
*Respiratory depression | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
* Respiratory depression | |||
* apnea | |||
* hypotension | |||
* paradoxical CNS stimulation | |||
===Common=== | ===Common=== | ||
* sedation | |||
* ataxia | |||
* disinhibition | |||
* dysarthria | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 10-20 hours | ||
*Metabolism: | *Metabolism: liver | ||
*Excretion: | *Excretion: renal | ||
*Mechanism of Action: | *Mechanism of Action: GABA receptor agonist | ||
==See Also== | ==See Also== | ||
| Line 41: | Line 72: | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:Neurology]] | |||
Latest revision as of 10:07, 15 July 2025
General
- Type: Benzodiazepine
- Dosage Forms: Tablet: 0.5, 1, 2 mg. IV solution: 2mg/ml, 4 mg/ml
- Common Trade Names: Ativan
Adult Dosing
- Active Seizure
- 2mg IV or IM
Pediatric Dosing
Seizure
- 0.1 mg/kg IV
Special Populations[1]
- Pregnancy Rating:
- Lactation:
- Lorazepam is present in breast milk
- Renal Dosing
- Adult
- PO: no adjustment necessary
- IV:
- Mild to moderate impairment
- No adjustment necessary
- Severe impairment
- Use not recommended
- Mild to moderate impairment
- Pediatric
- PO: not defined
- IV:
- Mild to moderate impairment
- No adjustment necessary
- Severe impairment
- Use not recommended
- Mild to moderate impairment
- Adult
- Hepatic Dosing
- Adult
- PO:
- Mild to moderate impairment: No adjustment necessary
- Severe impairment: May need lower doses, use caution
- IV:
- Mild to moderate impairment: No adjustment necessary
- Severe impairment: Use not recommended
- PO:
- Pediatric
- ≥ 12 years old: No adjustment necessary however use caution with severe hepatic disease
- Adult
Contraindications
- Allergy to class/drug
- Respiratory depression
Adverse Reactions
Serious
- Respiratory depression
- apnea
- hypotension
- paradoxical CNS stimulation
Common
- sedation
- ataxia
- disinhibition
- dysarthria
Pharmacology
- Half-life: 10-20 hours
- Metabolism: liver
- Excretion: renal
- Mechanism of Action: GABA receptor agonist
See Also
References
- ↑ Lorazepam: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.