Sulfadiazine: Difference between revisions
ClaireLewis (talk | contribs) (Created page with "==Administration== *Type: Antibiotic *Dosage Forms: *Routes of Administration: Oral *Common Trade Names: ==Adult Dosing== *2-4g PO daily in 1-4 doses ==Pediatric Dosing...") |
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==Administration== | ==Administration== | ||
*Type: [[Antibiotic]] | *Type: [[Antibiotic]] | ||
*Dosage Forms: | *Dosage Forms: Tablet, 500mg | ||
*Routes of Administration: Oral | *Routes of Administration: Oral | ||
*Common Trade Names: | *Common Trade Names: | ||
==Adult Dosing== | ==Adult Dosing== | ||
| Line 9: | Line 9: | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
* >2mo: 75-150 mg/kg PO daily in 1-4 doses | *>2mo: 75-150 mg/kg PO daily in 1-4 doses | ||
==Special Populations== | ==Special Populations== | ||
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===Serious=== | ===Serious=== | ||
*SJS/TEN | *SJS/TEN | ||
*Agranulocytosis, hemolytic anemia, leukopenia, thrombocytopenia, aplastic anemia | *Agranulocytosis, hemolytic anemia, leukopenia, thrombocytopenia, aplastic anemia | ||
*Crystalluria | *Crystalluria | ||
*Allergic Myocarditis | |||
===Common=== | ===Common=== | ||
*Rash | *Rash | ||
*Nausea/vomiting, diarrhea, abdominal pain | *Nausea/vomiting, diarrhea, abdominal pain | ||
*Tinnitus | |||
*Headache, Depression, Insomnia | |||
==Pharmacology== | ==Pharmacology== | ||
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<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:ID]] | |||
Latest revision as of 22:37, 23 September 2019
Administration
- Type: Antibiotic
- Dosage Forms: Tablet, 500mg
- Routes of Administration: Oral
- Common Trade Names:
Adult Dosing
- 2-4g PO daily in 1-4 doses
Pediatric Dosing
- >2mo: 75-150 mg/kg PO daily in 1-4 doses
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk has been demonstrated
- Renal dosing: use with caution
- Hepatic dosing: use with caution
Contraindications
- Allergy to class/drug
- Infants <2mo (except to treat congenital toxoplasmosis)
- Pregnant women at term
- Breastfeeding
Adverse Reactions
Serious
- SJS/TEN
- Agranulocytosis, hemolytic anemia, leukopenia, thrombocytopenia, aplastic anemia
- Crystalluria
- Allergic Myocarditis
Common
- Rash
- Nausea/vomiting, diarrhea, abdominal pain
- Tinnitus
- Headache, Depression, Insomnia
Pharmacology
- Half-life: 7-16.8h
- Metabolism: Hepatic
- Excretion: Mostly renal
Mechanism of Action
- Inhibits bacterial synthesis of folic acid