Strychnine: Difference between revisions
Ostermayer (talk | contribs) (Text replacement - "Category:Tox" to "Category:Toxicology") |
Neil.m.young (talk | contribs) (Text replacement - "==Diagnostic Evaluation==" to "==Evaluation==") |
||
| Line 16: | Line 16: | ||
{{Jaw spasms DDX}} | {{Jaw spasms DDX}} | ||
== | ==Evaluation== | ||
*Serum and urine tests for strychnine | *Serum and urine tests for strychnine | ||
Revision as of 02:43, 28 July 2016
Background
- Strychnine is a highly toxic substance, mimics generalized tetanus
- Antagonizes glycine release, but unlike TS, it has no effect on GABA release
Clinical Features
- Nausea and vomiting
- Opisthotonus while patient remaining alert
- Convulsions
- Eventually death through asphyxia
Differential Diagnosis
- Generalized tetanus
- Black widow spider bite
- Stiff-man syndrome
Jaw Spasms
- Acute tetanus
- Akathisia
- Conversion disorder
- Drug toxicity (anticholinergic, phenytoin, valproate, carbamazepine)
- Dystonic reaction
- Electrolyte abnormality
- Hypocalcemic tetany
- Magnesium
- Mandible dislocation
- Meningitis
- Peritonsillar abscess
- Rabies
- Seizure
- Strychnine poisoning
- Stroke
- Temporomandibular disorder
- Torticollis
Evaluation
- Serum and urine tests for strychnine
Management
- Supportive management
- Benzodiazepines for seizure
Disposition
- All patients should be admitted