Transfusion-related acute lung injury: Difference between revisions
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==Background== | ==Background== | ||
*Due to granulocyte recruitment and degranulation within the lung | |||
*More common with [[FFP]] and [[platelet]] transfusions (extremely rare with [[pRBC]] transfusion alone) | |||
**[[pRBCs]] do contain residual plasma and can have TRALI | |||
==Clinical Features== | ==Clinical Features== | ||
*[[ARDS]]-like symptoms | |||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
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==Diagnosis== | ==Diagnosis== | ||
*Time Frame: abrupt to within 6 hours of transfusion initiation | |||
==Management== | ==Management== | ||
**Strop transfusion | |||
**Treat like [[ARDS]] | |||
**Avoid diuresis | |||
==Disposition== | ==Disposition== | ||
*Bilateral pulmonary infiltrates due to noncardiogenic pulmonary edema within 6h of transfusion | |||
==See Also== | ==See Also== | ||
Revision as of 20:56, 4 February 2016
Background
- Due to granulocyte recruitment and degranulation within the lung
- More common with FFP and platelet transfusions (extremely rare with pRBC transfusion alone)
- pRBCs do contain residual plasma and can have TRALI
Clinical Features
- ARDS-like symptoms
Differential Diagnosis
Transfusion Reaction Types
- Acute
- Delayed
Diagnosis
- Time Frame: abrupt to within 6 hours of transfusion initiation
Management
- Strop transfusion
- Treat like ARDS
- Avoid diuresis
Disposition
- Bilateral pulmonary infiltrates due to noncardiogenic pulmonary edema within 6h of transfusion