Graft-vs-host disease: Difference between revisions
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==Background== | ==Background== | ||
*Acute vs Chronic | *Acute vs Chronic | ||
**Acute: 1-12 weeks post graft | **Acute: 1-12 weeks post graft (<100 days) | ||
**Chronic: >12 weeks | **Chronic: >12 weeks | ||
*Transplanted graft with immunologically competent cells stimulated by host antigens and host is incapable of mounting an effective immunologic response | *Transplanted graft with immunologically competent cells stimulated by host antigens and host is incapable of mounting an effective immunologic response | ||
*Occurs in leukemia/lymphoma or immunocompromised | *Occurs in leukemia/lymphoma or immunocompromised | ||
**Most commonly post HSCT: Hematopoietic stem cell transplant | |||
*Rare in solid organ transplant | |||
==Clinical Features== | ==Clinical Features== | ||
Revision as of 04:21, 1 February 2016
Background
- Acute vs Chronic
- Acute: 1-12 weeks post graft (<100 days)
- Chronic: >12 weeks
- Transplanted graft with immunologically competent cells stimulated by host antigens and host is incapable of mounting an effective immunologic response
- Occurs in leukemia/lymphoma or immunocompromised
- Most commonly post HSCT: Hematopoietic stem cell transplant
- Rare in solid organ transplant
Clinical Features
Differential Diagnosis
Transfusion Reaction Types
- Acute
- Delayed
Diagnosis
- LFT abnormalities
- Pancytopenia
Management
- Glucocorticoids
Disposition
See Also
- Transfusions
- Acute transfusion reaction
- Extravascular hemolytic tranfusion reaction
- Graft-vs-host disease