Strychnine: Difference between revisions
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==Clinical Features== | ==Clinical Features== | ||
*nausea and vomiting | *[[nausea and vomiting]] | ||
*opisthotonus while | *opisthotonus while patient remaining alert | ||
* | *[[Convulsions]] | ||
*eventually death through asphyxia | *eventually death through asphyxia | ||
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{{Jaw spasms DDX}} | {{Jaw spasms DDX}} | ||
== | ==Diagnosis== | ||
*Serum and urine tests for strychnine | |||
==Management== | ==Management== | ||
* | *Supportive management | ||
* | *[[Benzodiazepines]] for [[seizure]] | ||
==Disposition== | ==Disposition== | ||
* | *All patients should be admitted | ||
==See Also== | ==See Also== | ||
*[[Tetanus]] | *[[Tetanus]] | ||
== | ==References== | ||
rosen, 7th edition p1684 | rosen, 7th edition p1684 | ||
<references/> | <references/> | ||
Revision as of 22:55, 12 August 2015
Background
Strychnine is a highly toxic substance, mimics generalized tetanus. Antagonizes glycine release, but unlike TS, it has no effect on GABA release.
Clinical Features
- nausea and vomiting
- opisthotonus while patient remaining alert
- Convulsions
- eventually death through asphyxia
Differential Diagnosis
- generalized tetanus
- Black widow spider bite
- stiff-man syndrome
Jaw Spasms
- Acute tetanus
- Akathisia
- Conversion disorder
- Drug toxicity (anticholinergic, phenytoin, valproate, carbamazepine)
- Dystonic reaction
- Electrolyte abnormality
- Hypocalcemic tetany
- Magnesium
- Mandible dislocation
- Meningitis
- Peritonsillar abscess
- Rabies
- Seizure
- Strychnine poisoning
- Stroke
- Temporomandibular disorder
- Torticollis
Diagnosis
- Serum and urine tests for strychnine
Management
- Supportive management
- Benzodiazepines for seizure
Disposition
- All patients should be admitted
See Also
References
rosen, 7th edition p1684