Vitamin K deficiency: Difference between revisions
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=Background= | ==Background== | ||
#Cofactor for vitamin K-dependent clotting factors II, VII, IX, X | #Cofactor for vitamin K-dependent clotting factors II, VII, IX, X | ||
##Used by liver | ##Used by liver | ||
##Fat soluble | ##Fat soluble | ||
= | ===Causes=== | ||
#Nutritional deficiency | #Nutritional deficiency | ||
#Malabsorption | #Malabsorption | ||
#Cholestasis: since it is fat soluble and needs bile salts to be absorbed | #Cholestasis: since it is fat soluble and needs bile salts to be absorbed | ||
=Treatment | ==Clinical Features== | ||
#Fresh Frozen Plasma: 1ml contains 1U of each clotting factor | |||
#Consider Vitamin K oral or IV (subcutaneous not recommended): will take up to 24 hours to work and up to 2 weeks to wear off | ==Differential Diagnosis== | ||
{{Increased bleeding DDX}} | |||
==Treatment== | |||
#[[Fresh Frozen Plasma]]: 1ml contains 1U of each clotting factor | |||
#Consider [[Vitamin K]] oral or IV (subcutaneous not recommended): will take up to 24 hours to work and up to 2 weeks to wear off | |||
==Disposition== | |||
=See Also= | =See Also= | ||
Revision as of 12:40, 10 June 2015
Background
- Cofactor for vitamin K-dependent clotting factors II, VII, IX, X
- Used by liver
- Fat soluble
Causes
- Nutritional deficiency
- Malabsorption
- Cholestasis: since it is fat soluble and needs bile salts to be absorbed
Clinical Features
Differential Diagnosis
Coagulopathy
Platelet Related
- Too few
- Nonfunctional
Factor Related
- Acquired (Drug Related)
- Warfarin (Coumadin)
- Unfractionated heparin
- Low molecular weight heparin (i.e. enoxaparin (Lovenox), dalteparin)
- Factor Xa Inhibitors (e.g. rivaroxaban, apixaban, fondaparinux, edoxaban)
- Direct thrombin inhibitors (e.g. dabigatran, argatroban, bivalirudin)
- Illness induced
- Genetic
Treatment
- Fresh Frozen Plasma: 1ml contains 1U of each clotting factor
- Consider Vitamin K oral or IV (subcutaneous not recommended): will take up to 24 hours to work and up to 2 weeks to wear off