Sulfadiazine: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
*2-4g PO daily in 1-4 doses | *2-4g PO daily in 1-4 doses | ||
===Indications by Disease=== | |||
{{#ask: [[Has DrugName::Sulfadiazine]] [[Has Population::Adult]] | |||
|?Treats disease=Disease | |||
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|?Has Context=Context | |||
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==Pediatric Dosing== | ==Pediatric Dosing== | ||
*>2mo: 75-150 mg/kg PO daily in 1-4 doses | *>2mo: 75-150 mg/kg PO daily in 1-4 doses | ||
===Indications by Disease=== | |||
{{#ask: [[Has DrugName::Sulfadiazine]] [[Has Population::Pediatric]] | |||
|?Treats disease=Disease | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|format=table | |||
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==Special Populations== | ==Special Populations== | ||
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<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:ID]] | |||
Latest revision as of 02:39, 20 March 2026
Administration
- Type: Antibiotic
- Dosage Forms: Tablet, 500mg
- Routes of Administration: Oral
- Common Trade Names:
Adult Dosing
- 2-4g PO daily in 1-4 doses
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Toxoplasmosis | 1g PO q6hrs | Immunocompetent with Pyrimethamine |
| Toxoplasmosis | 1500mg PO q6hrs | Immunosuppressed with Pyrimethamine |
Pediatric Dosing
- >2mo: 75-150 mg/kg PO daily in 1-4 doses
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Toxoplasmosis | 50mg/kg PO BID | Congenital/Pediatric |
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk has been demonstrated
- Renal dosing: use with caution
- Hepatic dosing: use with caution
Contraindications
- Allergy to class/drug
- Infants <2mo (except to treat congenital toxoplasmosis)
- Pregnant women at term
- Breastfeeding
Adverse Reactions
Serious
- SJS/TEN
- Agranulocytosis, hemolytic anemia, leukopenia, thrombocytopenia, aplastic anemia
- Crystalluria
- Allergic Myocarditis
Common
- Rash
- Nausea/vomiting, diarrhea, abdominal pain
- Tinnitus
- Headache, Depression, Insomnia
Pharmacology
- Half-life: 7-16.8h
- Metabolism: Hepatic
- Excretion: Mostly renal
Mechanism of Action
- Inhibits bacterial synthesis of folic acid