Acanthosis nigricans: Difference between revisions
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*Associated with GI and GU malignancies, which may have concomitant weight loss | *Associated with GI and GU malignancies, which may have concomitant weight loss | ||
*Non malignant form may be associated with endocrine abnormalities, such as insulin resistance | *Non malignant form may be associated with endocrine abnormalities, such as insulin resistance | ||
==Clinical Features== | ==Clinical Features== | ||
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==Evaluation== | ==Evaluation== | ||
===Workup=== | |||
===Diagnosis=== | ===Diagnosis=== | ||
*Red flags for ''malignant'' acanthosis nigricans: | *Red flags for ''malignant'' acanthosis nigricans: | ||
Latest revision as of 16:14, 11 December 2024
Background
- Multiple forms, but malignant acanthosis nigricans is most important
- Most commonly associated with colonic adenocarcinoma, gastric cancer, ovarian cancer
- Also associated with other dermal manifestations of internal cancers
- Associated with GI and GU malignancies, which may have concomitant weight loss
- Non malignant form may be associated with endocrine abnormalities, such as insulin resistance
Clinical Features
- Hyperpigmented, velvety
- Plaques
- Most commonly intertriginous areas, posterior neck
- May have concurrent acrochordons, skin tags
Differential Diagnosis
Dark raised skin lesions
Evaluation
Workup
Diagnosis
- Red flags for malignant acanthosis nigricans:
- Oral involvement (up to 50%)
- Rapid appearance of lesions
- Extensive involvement
- Older adult
- Unexplained weight loss
- Lesions in atypical sites such as palms/soles, mucous membranes
Management
Disposition
External Links
See Also
References
- Schwarzenberger K, Callen JP. Chapter 53: Dermatologic manifestations in patients with systemic disease. In: Bolognia JL, Schaffer JV, Cerroni L, eds. Dermatology. 4th ed. Philadelphia, PA: Elsevier; 2017:820.