Anticonvulsants: Difference between revisions

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! Drug !! Dose !! Infusion Rate !! Age !! Comments/Cautions
! Drug !! Dose !! Infusion Rate !! Age !! Comments/Cautions
|-
|-
| [[Levetiracetam]] || 60 mg/kg/dose IV/IO (MAX 3000 mg/dose) || Over 5 minutes || Any || Most commonly used agent
| [[Levetiracetam]] ||  
*60 mg/kg/dose IV/IO  
*MAX: 3000 mg/dose  
|| Over 5 minutes || Any || Most commonly used agent
|-
|-
| [[Fosphenytoin]] || 20 mg phenytoin equivalent (PE)/kg/dose IV/IO/IM (MAX 1000 PE/dose) || Over 10 minutes || Any || Choose alternate drug if on phytoin at home; may decrease BP/HR
| [[Fosphenytoin]] ||  
*20 mg phenytoin equivalent (PE)/kg/dose IV/IO/IM  
*MAX: 1000 PE/dose
|| Over 10 minutes || Any || Choose alternate drug if on phenytoin at home; may decrease BP/HR
|-
|-
| [[Valproic acid]] || 40 mg/kg/dose IV/IO (MAX 3000 mg/dose) || Over 10 minutes || >2 years || Caution in patients with liver dysfunciton, mitochondrial disease, urea disorder, thrombocytopenia, or unexplained developmental delay
| [[Valproic acid]] || *
40 mg/kg/dose IV/IO  
*MAX: 3000 mg/dose
|| Over 10 minutes || >2 years || Caution in patients with liver dysfunction, mitochondrial disease, urea disorder, thrombocytopenia, or unexplained developmental delay
|-
|-
| [[Phenytoin]] || 20 mg/kg/dose IV/IO (MAX 1000 mg/dose) || Over 20 minutes || Any || Choose alternate drug if on phytoin at home; may decrease BP/HR
| [[Phenytoin]] ||  
*20 mg/kg/dose IV/IO  
*MAX: 1000 mg/dose
|| Over 20 minutes || Any || Choose alternate drug if on phenytoin at home; may decrease BP/HR
|-
|-
| [[Phenobarbital]] || 20 mg/kg/dose IV/IO (MAX 1000 mg/dose) || Over 20 minutes || <6 months || Repiratory depression, espeically in combination with benzos
| [[Phenobarbital]] ||  
*20 mg/kg/dose IV/IO  
*MAX: 1000 mg/dose
|| Over 20 minutes || <6 months || Respiratory depression, especially in combination with benzos
|}
|}


Revision as of 20:38, 19 October 2022

Pediatric Anticonvulsants Table

Drug Dose Infusion Rate Age Comments/Cautions
Levetiracetam
  • 60 mg/kg/dose IV/IO
  • MAX: 3000 mg/dose
 Over 5 minutes Any Most commonly used agent
Fosphenytoin
  • 20 mg phenytoin equivalent (PE)/kg/dose IV/IO/IM
  • MAX: 1000 PE/dose
 Over 10 minutes Any Choose alternate drug if on phenytoin at home; may decrease BP/HR
Valproic acid *

40 mg/kg/dose IV/IO

  • MAX: 3000 mg/dose
 Over 10 minutes >2 years Caution in patients with liver dysfunction, mitochondrial disease, urea disorder, thrombocytopenia, or unexplained developmental delay
Phenytoin
  • 20 mg/kg/dose IV/IO
  • MAX: 1000 mg/dose
 Over 20 minutes Any Choose alternate drug if on phenytoin at home; may decrease BP/HR
Phenobarbital
  • 20 mg/kg/dose IV/IO
  • MAX: 1000 mg/dose
 Over 20 minutes <6 months Respiratory depression, especially in combination with benzos

See Also

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