Ibuprofen: Difference between revisions
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==General== | ==General== | ||
*Type: [[NSAID]] | *Type: [[NSAID]] | ||
*Dosage Forms: | *Dosage Forms: Tablets: 100, 200, 400, 600, 800 mg. Suspension: 20mg/ml, 40 mg/ml | ||
*Common Trade Names: Advil; Motrin | *Common Trade Names: Advil; Motrin | ||
==Adult Dosing== | ==Adult Dosing== | ||
*600mg | *800mg PO Q8hours | ||
**400mg has been shown to be as effective at pain reduction as 600mg and 800mg<ref>Motov S, Masoudi A, Drapkin J, et al. Comparison of Oral Ibuprofen at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial. Ann Emerg Med. 2019;74(4):530-537. doi:10.1016/j.annemergmed.2019.05.037</ref> | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
* | *10mg/kg PO Q6hours | ||
*Max: | *Max: 40mg/kg/day | ||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C (1st-2nd trimester), D (3rd trimester) | ||
*Lactation: | *[[Lactation risk categories]]: L4; enters breast milk, decreases milk supply | ||
*Renal Dosing | *Renal Dosing | ||
**Adult | **Adult: no adjustment | ||
**Pediatric | **Pediatric: no adjustment | ||
*Hepatic Dosing | *Hepatic Dosing | ||
**Adult | **Adult: not defined | ||
**Pediatric | **Pediatric: not defined | ||
==Contraindications== | ==Contraindications== | ||
| Line 32: | Line 33: | ||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*[[Anaphylaxis]] | |||
*[[GI bleeding]] | *[[GI bleeding]] | ||
* | *[[Peptic ulcer disease]], gastric perforation, [[bowel perforation]] | ||
*Thromboycytopenia | |||
*[[Agranulocytosis]] | |||
*[[Steven-Johnson Syndrome]] | |||
*[[Nephrotoxicity]] | |||
===Common=== | ===Common=== | ||
*[[Dyspepsia]] | |||
*[[Nausea]] | |||
*[[Abdominal pain]] | |||
*[[Constipation]] | |||
*[[Headache]] | |||
*[[Dizziness]] | |||
*[[Rash]] | |||
*Fluid retention | |||
*Ecchymosis | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 1.8 - 2 hr | ||
*Metabolism: | *Metabolism: liver | ||
*Excretion: | *Excretion: Urine | ||
*Mechanism of Action: | *Mechanism of Action: exact mechanism unknown; inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis | ||
==See Also== | ==See Also== | ||
*[[NSAID]] | |||
*[[NSAID toxicity]] | |||
== | ==References== | ||
<references/> | |||
[[Category:Pharmacology]] | |||
[[Category: | |||
Latest revision as of 22:45, 7 March 2021
General
- Type: NSAID
- Dosage Forms: Tablets: 100, 200, 400, 600, 800 mg. Suspension: 20mg/ml, 40 mg/ml
- Common Trade Names: Advil; Motrin
Adult Dosing
- 800mg PO Q8hours
- 400mg has been shown to be as effective at pain reduction as 600mg and 800mg[1]
Pediatric Dosing
- 10mg/kg PO Q6hours
- Max: 40mg/kg/day
Special Populations
- Pregnancy Rating: C (1st-2nd trimester), D (3rd trimester)
- Lactation risk categories: L4; enters breast milk, decreases milk supply
- Renal Dosing
- Adult: no adjustment
- Pediatric: no adjustment
- Hepatic Dosing
- Adult: not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
- Cardiovascular
- May cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal
- Contraindicated for treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery
- Gastrointestinal risk
- Increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal
- Elderly patients are at greater risk for serious GI events.
- Increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal
Adverse Reactions
Serious
- Anaphylaxis
- GI bleeding
- Peptic ulcer disease, gastric perforation, bowel perforation
- Thromboycytopenia
- Agranulocytosis
- Steven-Johnson Syndrome
- Nephrotoxicity
Common
- Dyspepsia
- Nausea
- Abdominal pain
- Constipation
- Headache
- Dizziness
- Rash
- Fluid retention
- Ecchymosis
Pharmacology
- Half-life: 1.8 - 2 hr
- Metabolism: liver
- Excretion: Urine
- Mechanism of Action: exact mechanism unknown; inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis
See Also
References
- ↑ Motov S, Masoudi A, Drapkin J, et al. Comparison of Oral Ibuprofen at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial. Ann Emerg Med. 2019;74(4):530-537. doi:10.1016/j.annemergmed.2019.05.037