Aspirin: Difference between revisions

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==General==
==General==
*Type: [[Antiplatelet]]
*Type: [[Antiplatelet]], [[NSAID]]
*Dosage Forms:
*Dosage Forms: tablet, delayed-release tablet, chewable tablet, enteric-coated tablet, oral chewing gum, extended release capsule
*Common Trade Names: Aspirin, Baby Aspirin, ASA
*Common Trade Names: Aspirin, Baby Aspirin, ASA
*Usage:  
*Usage: Analgesic, antipyretic, antiplatelet
**Pain reliever/fever reducer
**Antiplatelet


==Adult Dosing==
==Adult Dosing==
*325 to 650 mg orally or rectally every 4 hours as needed, not to exceed 4 g/day
*325 to 650mg orally or rectally every 4 hours as needed, not to exceed 4 g/day
*324 mg chewable for ACS
*324mg chewable for [[ACS]]
*81 mg (baby) Aspirin common daily cardiac risk reduction dose
*81mg (baby) Aspirin common daily cardiac risk reduction dose


==Pediatric Dosing==
==Pediatric Dosing==
*2 to 11 years: 10 to 15 mg/kg orally or rectally every 4 to 6 hours as needed, not to exceed 4 g/day.
'''''Avoid use''' in children, especially those with viral syndrome, due to risk of [[Reye syndrome]]''
*12 years or older: 325 to 650 mg orally or rectally every 4 hours as needed, not to exceed 4 g/day
*Fever, pain
**>12yo: 325 to 650mg PO or PR q4-6h
*2-11yo: 10 to 15 mg/kg PO or PR q4-6h
*Kawasaki: 80-100 mg/kg/day (divided q4-6h) PO until afebrile 48-72h or day 14, then 3-5mg/kg/day until no evidence of coronary changes
*Stroke: 1 to 5 mg/kg/day PO
*Juvenile RA: 90-130 mg/kg/day PO divided q4-6h


==Special Populations==
==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: D
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C (1st-2nd trimester), D (3rd trimester)
*Lactation: best avoided, low dose may be considered for antiplatelet
*Lactation: Infant risk cannot be ruled out
*Renal Dosing
*Renal Dosing: if CrCl <10, avoid use
**Adult: if CrCl<10, avoid use
*Hepatic Dosing: avoid if severe impairment
**Pediatric: if CrCl<10, avoid use
*Hepatic Dosing
**Adult: not defined
**Pediatric: not defined


==Contraindications==
==Contraindications==
*Allergy to class/drug
*Allergy to class/drug
**Hives, Facial swelling, Asthma, Shock
* Syndrome of asthma, rhinitis, and nasal polyps
*Bleeding, Ulcers, Asthma
 


==Adverse Reactions==
==Adverse Reactions==
===Serious===
===Serious===
*[[Aspirin (Salicylate) Toxicity]]
*See [[Aspirin (Salicylate) Toxicity]]
*[[Reye syndrome]] - Children and teenagers should not use this medicine for chicken pox or flu symptoms  
*[[Reye syndrome]] - Children and teenagers should not use this medicine for chicken pox or viral symptoms  
 
*GI ulcer
*Hemorrhage
*Exudative age-related macular degeneration
*Bronchospasm
*Tinnitus
*Angioedema
===Common===
===Common===




==Pharmacology==
==Pharmacology==
*Half-life:  
*Half-life: 20-60m, Salicylic acid: 6h
*Metabolism:  
*Metabolism: Hepatic
*Excretion:  
*Excretion: Renal, dialyzable
*Mechanism of Action:
*Mechanism of Action: Irreversible cyclooxygenase inhibitor, thus preventing prostaglandin synthesis and platelet activation


==See Also==
==See Also==
*[[Aspirin (Salicylate) Toxicity]]
*[[Aspirin (Salicylate) Toxicity]]
*[[Antiplatelet medications]]
*[[Antiplatelet agent reversal]]


==Sources==
==References==
http://www.drugs.com/aspirin.html
http://www.drugs.com/aspirin.html


<references/>
<references/>
[[Category:Drugs]]
[[Category:Pharmacology]]

Latest revision as of 03:06, 6 March 2021

General

  • Type: Antiplatelet, NSAID
  • Dosage Forms: tablet, delayed-release tablet, chewable tablet, enteric-coated tablet, oral chewing gum, extended release capsule
  • Common Trade Names: Aspirin, Baby Aspirin, ASA
  • Usage: Analgesic, antipyretic, antiplatelet

Adult Dosing

  • 325 to 650mg orally or rectally every 4 hours as needed, not to exceed 4 g/day
  • 324mg chewable for ACS
  • 81mg (baby) Aspirin common daily cardiac risk reduction dose

Pediatric Dosing

Avoid use in children, especially those with viral syndrome, due to risk of Reye syndrome

  • Fever, pain
    • >12yo: 325 to 650mg PO or PR q4-6h
  • 2-11yo: 10 to 15 mg/kg PO or PR q4-6h
  • Kawasaki: 80-100 mg/kg/day (divided q4-6h) PO until afebrile 48-72h or day 14, then 3-5mg/kg/day until no evidence of coronary changes
  • Stroke: 1 to 5 mg/kg/day PO
  • Juvenile RA: 90-130 mg/kg/day PO divided q4-6h

Special Populations

  • Pregnancy Rating: C (1st-2nd trimester), D (3rd trimester)
  • Lactation: Infant risk cannot be ruled out
  • Renal Dosing: if CrCl <10, avoid use
  • Hepatic Dosing: avoid if severe impairment

Contraindications

  • Allergy to class/drug
  • Syndrome of asthma, rhinitis, and nasal polyps


Adverse Reactions

Serious

  • See Aspirin (Salicylate) Toxicity
  • Reye syndrome - Children and teenagers should not use this medicine for chicken pox or viral symptoms
  • GI ulcer
  • Hemorrhage
  • Exudative age-related macular degeneration
  • Bronchospasm
  • Tinnitus
  • Angioedema

Common

Pharmacology

  • Half-life: 20-60m, Salicylic acid: 6h
  • Metabolism: Hepatic
  • Excretion: Renal, dialyzable
  • Mechanism of Action: Irreversible cyclooxygenase inhibitor, thus preventing prostaglandin synthesis and platelet activation

See Also

References

http://www.drugs.com/aspirin.html


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