Vitamin K deficiency: Difference between revisions

Latest revision as of 18:53, 23 February 2021

Cofactor for vitamin K-dependent clotting factors II, VII, IX, X
- Used by liver
- Fat soluble

Nutritional deficiency
Malabsorption (pancreatic insufficiency, celiac sprue, cystic fibrosis, etc)
Cholestasis: since it is fat soluble and needs bile salts to be absorbed
Neonates lack intestinal bacteria that produce vitamin K and therefore require supplementation at birth
- If no vitamin K given, neonate at increased risk of spontaneous hemorrhage

Fresh Frozen Plasma: 1ml contains 1U of each clotting factor
Consider Vitamin K oral or IV (subcutaneous not recommended): will take up to 24 hours to work and up to 2 weeks to wear off

Authors:

@@ Line 1: / Line 1: @@
-Is cofactor for vit k dependent clotting factors 2-7-9-10
+==Background==
+*Cofactor for vitamin K-dependent clotting factors II, VII, IX, X
+**Used by liver
+**Fat soluble
-- used by liver
+===Causes===
+*Nutritional deficiency
+*Malabsorption (pancreatic insufficiency, [[celiac sprue]], [[cystic fibrosis]], etc)
+*Cholestasis: since it is fat soluble and needs bile salts to be absorbed
+*Neonates lack intestinal bacteria that produce vitamin K and therefore require supplementation at birth
+**If no vitamin K given, neonate at increased risk of spontaneous hemorrhage
-- fat soluble
+==Clinical Features==
+*[[Coagulopathy|Increased bleeding]]
+==Differential Diagnosis==
+{{Increased bleeding DDX}}
-Due to
+{{Vitamin deficiencies DDX}}
-- nutritional def
+==Management==
+*[[Fresh Frozen Plasma]]: 1ml contains 1U of each clotting factor
-- malabsorption- since is fat soluble
+*Consider [[Vitamin K]] oral or IV (subcutaneous not recommended): will take up to 24 hours to work and up to 2 weeks to wear off
-- cholestasis- need bile salts to absorb vit k
-Warfarin OD
-- hold coumadin
-- vit k- works in 12- 24 hrs
-- FFP- risk viral transmission or vol overload
+==Disposition==
+==See Also==
+*[[Warfarin (Coumadin) Reversal]]
+*[[Coagulopathy (Main)]]
+==External Links==
+[https://www.cdc.gov/ncbddd/vitamink/facts.html CDC: Vitamin K Deficiency Bleeding]
+==References==
+[[Category:Pharmacology]]
 [[Category:Heme/Onc]]
+[[Category:FEN]]