Acanthosis nigricans: Difference between revisions
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==Malignant Acanthosis Nigricans<ref>Miller JH et al. Acanthosis Nigricans Clinical Presentation. eMedicine. Dec 3, 2015. http://emedicine.medscape.com/article/1102488-clinical#showall.</ref>== | ==Malignant Acanthosis Nigricans<ref>Miller JH et al. Acanthosis Nigricans Clinical Presentation. eMedicine. Dec 3, 2015. http://emedicine.medscape.com/article/1102488-clinical#showall.</ref>== | ||
*Associated with other dermal manifestations of internal cancers | *Associated with other dermal manifestations of internal cancers | ||
*Most commonly associated with [[colon cancer|colonic adenocarcinoma]], gastric cancer | *Most commonly associated with [[colon cancer|colonic adenocarcinoma]], gastric cancer, ovarian cancer | ||
*Red flags: | *Red flags: | ||
**Up to 50% of malignant acanthosis nigricans have oral involvement | **Up to 50% of malignant acanthosis nigricans have oral involvement | ||
Revision as of 17:26, 31 October 2019
Background
- Multiple forms, but malignant acanthosis nigricans is most important
- Clinically indistinguishable from benign form
Clinical Features
- Hyperpigmented, velvety
- Plaques
- Most commonly intertriginous areas, posterior neck
- May have concurrent acrochordons, skin tags
Malignant Acanthosis Nigricans[1]
- Associated with other dermal manifestations of internal cancers
- Most commonly associated with colonic adenocarcinoma, gastric cancer, ovarian cancer
- Red flags:
- Up to 50% of malignant acanthosis nigricans have oral involvement
- Rapid appearance of lesions
- Extensive involvement
- Older adult
- Unexplained weight loss
- Lesions in atypical sites such as palms/soles, mucous membranes
See Also
References
- ↑ Miller JH et al. Acanthosis Nigricans Clinical Presentation. eMedicine. Dec 3, 2015. http://emedicine.medscape.com/article/1102488-clinical#showall.