Pyrazinamide

Administration

• Type: Antibiotic, anti-TB
• Dosage Forms:
• Routes of Administration: Oral
• Common Trade Names:

Adult Dosing

• 40-55 kg: 1000mg PO daily OR 1500mg PO 3 times per week OR 2000mg PO 2 times per week in combination with other agents
• 56-75kg: 1500mg PO daily OR 2500mg PO 3 times per week OR 3000mg PO 2 times per week in combination with other agents
• 76-90kg: 2000mg PO daily OR 3000mg PO 3 times per week OR 4000mg PO 2 times per week in combination with other agents

Pediatric Dosing

• 15 to 30 mg/kg PO daily (max 2000mg/day) OR 50mg/kg PO 2 times per week in combination with other agents

Special Populations

• Pregnancy Rating: C
• Lactation risk: Infant risk cannot be ruled out
• Renal dosing, CrCl <30mL/min: 25-35mg/kg 3 times per week (after HD, if applicable)
• Hepatic dosing: contraindicated in severe liver damage

Contraindications

• Allergy to class/drug
• Severe hepatic damage
• Acute gout

Adverse Reactions

Serious

• Hepatotoxicity
• Anemia

Common

• Nausea/vomiting
• Arthralgia
• Hyperuricemia

Pharmacology

• Half-life: 6.7-12.3h, longer in cirrhosis and/or ESRD
• Metabolism: hepatic
• Excretion: Mostly renal

Mechanism of Action

• Nicotinamide analogue, exact antitubercular mechanism unknown

See Also

• Tuberculosis