Fomepizole: Difference between revisions
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==Administration== | ==Administration== | ||
*Type: Alcohol dehydrogenase inhibitor | *Type: Alcohol dehydrogenase inhibitor, [[antidote]] | ||
*Routes of Administration: Intravenous | *Routes of Administration: Intravenous | ||
*Common Trade Names: Antizol | *Common Trade Names: Antizol | ||
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===Hemodialysis Dosing=== | ===Hemodialysis Dosing=== | ||
For patients undergoing hemodialysis for complications associated with toxic alcohol ingestion, dosing should be adjusted in consultation with a nephrologist. | *For patients undergoing hemodialysis for complications associated with toxic alcohol ingestion, dosing should be adjusted in consultation with a nephrologist. | ||
===Hepatic Dosing=== | ===Hepatic Dosing=== | ||
Fomepizole is metabolized in the liver, specific dosing adjustments for hepatic impairment have not been developed. | *Fomepizole is metabolized in the liver, specific dosing adjustments for hepatic impairment have not been developed. | ||
==Contraindications== | ==Contraindications== | ||
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==Mechanism of Action== | ==Mechanism of Action== | ||
Competitively inhibits alcohol dehydrogenase. | *Competitively inhibits alcohol dehydrogenase. | ||
==See Also== | ==See Also== | ||
Latest revision as of 20:01, 22 September 2019
Administration
- Type: Alcohol dehydrogenase inhibitor, antidote
- Routes of Administration: Intravenous
- Common Trade Names: Antizol
Adult Dosing
- Loading: 15 mg/kg
- Maintenance: 10 mg/kg every 12 hours
Pediatric Dosing
- Loading: 15 mg/kg
- Maintenance: 10 mg/kg every 12 hours
Special Populations
- Pregnancy Rating: C
- Lactation risk: Unknown if excreted in breast mild
Hemodialysis Dosing
- For patients undergoing hemodialysis for complications associated with toxic alcohol ingestion, dosing should be adjusted in consultation with a nephrologist.
Hepatic Dosing
- Fomepizole is metabolized in the liver, specific dosing adjustments for hepatic impairment have not been developed.
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Bradycardia
- Hypotension
- Shock
- Anemia
- Disseminated intravascular coagulation (DIC)
Common
- Headache
- Nausea
Pharmacology
- Half-life: Not calculated
- Metabolism: Hepatic
- Excretion: Urine
Mechanism of Action
- Competitively inhibits alcohol dehydrogenase.
See Also
References
- Lexicomp