Lithium: Difference between revisions
Neil.m.young (talk | contribs) (Text replacement - "0 mg" to "0mg") |
|||
| Line 25: | Line 25: | ||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*Toxicity (see [[Lithium toxicity]] | *Toxicity (see [[Lithium toxicity]]) | ||
*Seizure, ataxia, raised ICP | *Seizure, ataxia, raised ICP | ||
*Angioedema | *Angioedema | ||
*Erythema multiforme | *Erythema multiforme | ||
===Common=== | ===Common=== | ||
*Hypothroidism, weight gain | *Hypothroidism, weight gain | ||
Revision as of 12:50, 26 February 2018
Administration
- Type:
- Dosage Forms:
- Routes of Administration: oral
- Common Trade Names:
Adult Dosing
- Maintenance: 300mg PO 3 to 4 times daily; desired serum lithium level 0.6 to 1.2 mEq/L
- Acute manic episode: 600mg PO 3 times daily; desired serum lithium level 1 to 1.5 mEq/L
Pediatric Dosing
Safety/efficacy not established in children <12yo
Special Populations
- Pregnancy Rating: D
- Lactation risk: infant risk cannot be ruled out
Renal Dosing
- Adult:
- Pediatric:
Hepatic Dosing
- Adult:
- Pediatric:
Contraindications
- Allergy to class/drug
- Dehydration, cardiovascular disease, sodium depletion, concurrent diuretics, renal disease: needs inpatient monitoring if treatment required
Adverse Reactions
Serious
- Toxicity (see Lithium toxicity)
- Seizure, ataxia, raised ICP
- Angioedema
- Erythema multiforme
Common
- Hypothroidism, weight gain
- Nephrotoxicity
- Fine tremor, hyperreflexia
- Leukocytosis
- Nausea, gastritis
- Acne
Pharmacology
- Half-life: 14-50hr
- Metabolism: Renal
- Excretion: Renal