ACTH (cosyntropin) stimulation test: Difference between revisions

Latest revision as of 20:09, 30 May 2017

Background

ACTH (cosyntropin) stimulation test measures how well the adrenal glands respond to adrenocorticotropic hormone (ACTH)
ACTH is a hormone produced in the pituitary gland that stimulates the adrenal glands to release a hormone called cortisol
Man-made form of ACTH is called cosyntropin

Test

Before: Draw serum cortisol
Time 0: Give 0.25mg IM/IV of ACTH (Cosyntropin) over 2min (0.125mg if <2yrs old)
Time 30: Draw serum cortisol
Time 60: Draw serum cortisol & give 100mg hydrodortison IVP

Normal Response: Cortisol level doubles from baseline after Cosyntropin administration
Adrenal Insufficiency: Cortisol level fails to rise after Cosyntropin administration

Management

If abnormal test, can give:
- Dexamethasone 6mg IV OR Hydrocortisone 100mg IV

References

Authors:

@@ Line 1: / Line 1: @@
-Cosyntropin
+==Background==
-#Before: Draw serum cortisol
+*ACTH (cosyntropin) stimulation test measures how well the adrenal glands respond to adrenocorticotropic hormone (ACTH)
-#Time 0: ^0.25mg IM/IV over 2min
+*ACTH is a hormone produced in the pituitary gland that stimulates the adrenal glands to release a hormone called cortisol
-#Time 30: Draw serum cortisol
+*Man-made form of ACTH is called cosyntropin
-#Time 60: Draw serum cortisol & give 100mg hydrodortison IVP
-^0.125mg if <2yrs old
-Normal Response: Cortisol level doubles from baseline after Cosyntropin administration
-Adrenal Insufficiency: Cortisol level fails to rise after Cosyntropin administration
-==Treatment==
+==Test==
-#Then give either
+#Before: Draw serum cortisol
-##dexamethasone 6mg IV
+#Time 0: Give 0.25mg IM/IV of ACTH (Cosyntropin) over 2min (0.125mg if <2yrs old)
-##OR
+#Time 30: Draw serum cortisol
-##Hydrocortisone 100mg IV
+#Time 60: Draw serum cortisol &amp; give 100mg hydrodortison IVP
-==Source ==
+*'''Normal Response:''' Cortisol level doubles from baseline after Cosyntropin administration
-/22/06 DONALDSON (from Pharmacopoeia)
+*'''Adrenal Insufficiency:''' Cortisol level fails to rise after Cosyntropin administration
-Emedicine Adrenal Crisis in Emergency Medicine
-[[Category:Endo]]
+==Management==
+*If abnormal test, can give:
+**[[Dexamethasone]] 6mg IV '''OR''' [[Hydrocortisone]] 100mg IV
+==See Also==
+*[[Adrenal crisis]]
+*[[Addison's disease]]
+==References==
+<references/>
+[[Category:Endocrinology]]