ACTH (cosyntropin) stimulation test: Difference between revisions
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* | ==Background== | ||
*ACTH (cosyntropin) stimulation test measures how well the adrenal glands respond to adrenocorticotropic hormone (ACTH) | |||
*ACTH is a hormone produced in the pituitary gland that stimulates the adrenal glands to release a hormone called cortisol | |||
*Man-made form of ACTH is called cosyntropin | |||
==Test== | |||
#Before: Draw serum cortisol | #Before: Draw serum cortisol | ||
#Time 0: | #Time 0: Give 0.25mg IM/IV of ACTH (Cosyntropin) over 2min (0.125mg if <2yrs old) | ||
#Time 30: Draw serum cortisol | #Time 30: Draw serum cortisol | ||
#Time 60: Draw serum cortisol & give 100mg hydrodortison IVP | #Time 60: Draw serum cortisol & give 100mg hydrodortison IVP | ||
*'''Normal Response:''' Cortisol level doubles from baseline after Cosyntropin administration | |||
*'''Adrenal Insufficiency:''' Cortisol level fails to rise after Cosyntropin administration | |||
*Normal Response: Cortisol level doubles from baseline after Cosyntropin administration | |||
*Adrenal Insufficiency: Cortisol level fails to rise after Cosyntropin administration | |||
== | ==Management== | ||
*If abnormal test, can give: | |||
**[[Dexamethasone]] 6mg IV '''OR''' [[Hydrocortisone]] 100mg IV | |||
==See Also== | |||
*[[Adrenal crisis]] | |||
*[[Addison's disease]] | |||
==References== | |||
<references/> | |||
[[Category: | [[Category:Endocrinology]] | ||
Latest revision as of 20:09, 30 May 2017
Background
- ACTH (cosyntropin) stimulation test measures how well the adrenal glands respond to adrenocorticotropic hormone (ACTH)
- ACTH is a hormone produced in the pituitary gland that stimulates the adrenal glands to release a hormone called cortisol
- Man-made form of ACTH is called cosyntropin
Test
- Before: Draw serum cortisol
- Time 0: Give 0.25mg IM/IV of ACTH (Cosyntropin) over 2min (0.125mg if <2yrs old)
- Time 30: Draw serum cortisol
- Time 60: Draw serum cortisol & give 100mg hydrodortison IVP
- Normal Response: Cortisol level doubles from baseline after Cosyntropin administration
- Adrenal Insufficiency: Cortisol level fails to rise after Cosyntropin administration
Management
- If abnormal test, can give:
- Dexamethasone 6mg IV OR Hydrocortisone 100mg IV