Warfarin-induced skin necrosis: Difference between revisions
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[[File:WarfarinNecrosis.png|thumb]] | [[File:WarfarinNecrosis.png|thumb]] | ||
==Background== | ==Background== | ||
*Differing half-lives of Vitamin-K dependent coagulation factors leads to relative protein C deficiency | *Differing half-lives of Vitamin-K dependent coagulation factors leads to relative protein C deficiency initially→ hypercoagulability | ||
*Onset usually in first week of starting [[warfarin]] | *Onset usually in first week of starting [[warfarin]] | ||
==Clinical Features== | ==Clinical Features== | ||
*Painful, red lesions over extremities, trunk, penis | *Painful, red lesions over extremities, trunk, penis | ||
*Start with erythematous | *Start with erythematous macule→ edema→ central purpuric zones → necrosis | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
Revision as of 19:36, 8 February 2017
Background
- Differing half-lives of Vitamin-K dependent coagulation factors leads to relative protein C deficiency initially→ hypercoagulability
- Onset usually in first week of starting warfarin
Clinical Features
- Painful, red lesions over extremities, trunk, penis
- Start with erythematous macule→ edema→ central purpuric zones → necrosis
Differential Diagnosis
Evaluation
Management
- Stop warfarin
- Low molecular weight heparin or unfractionated heparin