View source for Grey baby syndrome

==Background==
*A side effect of [[chloramphenicol]] affecting newborns of mothers who have been exposed to the drug
*Thought to be related to insufficient ability of the newborn's liver to metabolize the drug, as well as insufficient renal excretion

==Clinical Features==
*Symptoms usually occur within 1 week of exposure and include:
**Ashen gray color of the skin
**[[failure to thrive (peds)|Failure to thrive]]
**Poor appetite
**[[nausea and vomiting (peds)|Vomiting]]
**[[Hypotension]]
**[[Hypothermia]]

==Differential Diagnosis==
{{Sick neonate DDX}}

==Evaluation==
*Assess for alternate diagnoses

==Management==
*Stop [[chloramphenicol]] exposure
*[[Exchange transfusion]]
*Sometimes [[phenobarbital]] used for UGT induction

==Disposition==
*Admit

==See Also==

==External Links==

==References==
<references/>

[[Category:Pediatrics]]