View source for Methotrexate

==Administration==
*Type: Immunosuppressant/antineoplastic
*Dosage Forms:
*Routes of Administration: IV/IM, oral 
*Common Trade Names: 

==Adult Dosing==
*Ectopic pregnancy: Single-dose regimen: Methotrexate 50 mg/m2

==Pediatric Dosing==

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: X
*[[Lactation risk categories|Lactation risk]]: Infant risk has been determined (risk of serious adverse effects for infant)
===Renal Dosing===
*Adult:
*Pediatric:
===Hepatic Dosing===
*Adult:
*Pediatric:

==Contraindications==
*Allergy to class/drug
*Breastfeeding, pregnant, or possibility of impregnating someone
*Blood dyscrasias
*Chronic liver disease
==Adverse Reactions==
===Serious===
*Hepatotoxicity
*Nephrotoxicity
*Myelosuppression, aplastic anemia, pancytopenia
*Infectious disease
*Tumor lysis syndrome
*GI bleed
*Neurotoxicity, seizure
*Pericardial effusion
*TEN
===Common===
*Nausea/vomiting, diarrhea
*Stomatitis
*Leukopenia, thrombocytopenia
*Alopecia, photosensitivity, rash
*Dizziness
==Pharmacology==
*Half-life: 8-15hr
*Metabolism: Extensive hepatic and intracellular
*Excretion: Mostly renal. Dialyzable.

==Mechanism of Action==
*Inhibits dihydrofolate reductase--> blocks DNA synthesis and thus, cellular replication/repair
==Comments==

==See Also==

==References==
<references/>
[[Category:Pharmacology]]