Diazepam

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General

Adult Dosing

  • Anxiety
    • PO: 2 - 10 mg 2-4 times daily
  • Muscle spasm
    • PO: 2 - 10 mg 2-4 times daily
  • Sedation in ICU
    • IV: Loading dose: 5 - 10 mg, Maintenance dose: 0.03 - 0.1 mg/kg every 30 minutes to 6 hours

Pediatric Dosing

Special Populations

  • Pregnancy Rating: D
  • Lactation: Diazepam and metabolites are present in breast milk
  • Renal Dosing
    • Adult
      • Not defined
    • Pediatric
      • Not defined
  • Hepatic Dosing
    • Adult
      • Not defined, use with caution, do not used oral tablets in severe hepatic impairment
    • Pediatric
      • Not defined, use with caution, do not used oral tablets in severe hepatic impairment

Contraindications

  • Allergy to class/drug
  • severe hepatic impairment

Adverse Reactions

Serious

  • Respiratory/CNS depression
  • Hypotension
  • paradoxical CNS stimulation

Common

  • drowsiness
  • disinhibition
  • ataxia

Pharmacology

  • Half-life: 30-60 hours
  • Metabolism: Liver
  • Excretion: Urine
  • Mechanism of Action: GABA agonist

See Also

References

  • Diazepam: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.

Authors:

Ross Donaldson