You may have noticed algorithm diagrams supplementing various topics on WikEM. They’re part of the WikEM Algorithm Project, a continuing partnership with ddxof.com (differential diagnosis of). The WikEM algorithms are developed to serve as rapid emergency department references for differential diagnosis generation, clinical decision rule application, and critical management steps. They also serve as convenient teaching tools for educators.
Negative-pressure pulmonary edema (NPPE) occurs after a patient makes strong inspiratory effort against a blocked airway. The negative pressure causes hydrostatic edema that can be life-threatening if not but minimized if treated early, usually resolves after 24-48 hours.
Patients have and airway obstructive process either from an allergy, laryngospasm, trauma, and commonly in the case of hangings.
Tetrodotoxin is from the pufferfish, blue octopus and some poisonous frogs. Neurotoxicity results from inhibition of Na-K pumps causing paresthesias and rebound hypersensitivity. Like most poisons in toxicology, the treatment is aggressive supportive care.… Read more